Efficient Microwave-Assisted Synthesis of N-(2-Alkyl/aryl-4-phenyl-1H-imidazol-1-yl)-2-phenylacetamides

Abstract

An easy, efficient, and environmentally friendly method for the synthesis of N-(2-alkyl/aryl-4-phenyl-1H-imidazol-1-yl)-2-phenylacetamides from the reaction of phenyl acylbromides and phenylacetohydrazide derivatives has been presented. Shorter reaction times, simple workup procedure, no catalyst requirement, and use of small quantities of organic solvent are the most obvious advantages of this protocol.

Green Protocol: Catalyst-Free Synthesis of 2-Substituted Benzimidazoles under Ultrasound Irradiation

“…In our previous studies, we developed a green protocol for the synthesis of heterocyclic compounds under microwave irradiation. 9,[21][22][23][24][25][26][27][28] As an extension to our previous studies on the development of a green protocol for the synthesis of heterocyclic compounds, a far more effective and rapid method for the synthesis of benzimidazole derivatives is reported under ultrasonic irradiation in this study. We provide an alternative procedure for the synthesis of 2-substituted benzimidazoles using imino ester hydrochlorides, which were prepared according to the literature, 29,30 under ultrasonic and catalyst-free conditions leading to the products with good yields and in short reaction times.…”