Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1H)-dione

A Clean Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives

“…[4][5][6] The spirooxindole system is the core structure of many pharmacological agents and natural alkaloids. [7][8][9][10] For example, spirotryprostatins A and B, two natural alkaloids isolated from the fermentation broth of Aspergillus fumigatus, have been identified as two novel inhibitors of microtubule assembly, 8) and pteropodine and isopteropodine have been shown to modulate the function of muscarinic serotonin receptors. 10) Xanthene derivatives have been reported to possess diverse biological and therapeutic properties such as antibacterial, antiviral, and anti-inflammatory activities, as well as being useful in photodynamic therapy.…”

rac-cis-5-Methyl-2,3-diphenyl-1,3-thiazolidin-4-one

“…5-Methyl-2,3-diaryl-1,3-thiazolidinones are readily available by use of thiolactic acid in the preparation (Patel et al, 1976) and show antimicrobial activity (Piscopo et al, 1988;Piscopo, Diurno, Gagliardi, Mazzoni, Parrilli & Veneruso, 1989;Piscopo, Diurno, Gagliardi, Mazzoni, De Franceso & Veneruso, 1989;. However, while the crystal structures of a number of 5-methyl-1,3-thiazolidin-4-ones have been reported (Rang et al, 1997;Ö zturk et al, 2000;Dandia et al;2006;Yalçin et al, 2008;Akkurt et al, 2010Akkurt et al, , 2011Akkurt et al, , 2012Ostapiuk et al, 2012;Jiang et al, 2012), only two of them were 2,3-diaryl substituted (Ö zturk et al, 2000;Dandia et al;2006). Herein, we report the synthesis and crystal structure of the cis isomer of rac-5-methyl-2,3-diphenyl-1,3-thiazolidin-4-one.…”

An Efficient Synthesis of 1-Thia-5-azaspiro[5.5]undec-2-ene and its Recyclization to 1,5-Diazaspiro[5.5]undec-2-ene and/or Spiro-Thieno[2,3-d]pyrimidin-4(1H)-one Derivatives

“…These compounds may display pronounced antimicrobial [1], analgesic [2], antiinflammatory [2], antimycobacterial [3], antifungal [4], antitumor [5,6], and antiviral [5,6] activities. Furthermore, 1,3-thiazines are an important type of heterocycles showing also a wide variety of related properties [7 -11].…”