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A simple and fast three-component diastereoselective synthesis of biologically important spiro scaffold 4 was carried out in reasonable purity starting from readily available 1H-indole-2,3-dione 1, ethyl cyanoacetate 2 and 4-hydroxycoumarin 3 under microwave in high yield (88%-92%) and short time.

Spiro[3H-indole-3,2'-thiazolidine]-3'(1,2,4-triazol-3-yl)-2,4'(1H)-dione. -A series of spiro compounds (IV) (12 examples) is efficiently prepared in high yields and within a few minutes by the microwave-assisted three-component cyclocondensation of indoles, heterocyclic amines, and thioglycolic acids using a clay as support. All products exhibit good in vitro antifungal activity against 3 pathogenic fungi. -(DANDIA*, A.; SINGH, R.; KHATURIA, S.; MERIENNE, C.; MORGANT, G.; LOUPY, A.; Bioorg.

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