Microwave enhanced solid support synthesis of fluorine containing benzopyrano-triazolo-thiadiazepines as potent anti-fungal agents

Synthesis of Indane‐Based 1,5‐Benzothiazepines Derived from 3‐Phenyl‐2,3‐dihydro‐1H‐inden‐1‐one and Antimicrobial Studies Thereof

“…Further, the carbons C 11 , C 11a , and C 12 of 1,5‐benzothiazepines ( 5a – t ) are chiral centers, and their stereochemistry has been established on the basis of their coupling constant ( J ) values. The coupling constant ( J ) values signify that C 11 –H and C 11a –H protons are trans oriented, and C 11a –H and C 12 –H are cis oriented, which find support from the coupling constant ( J ) values of the similar protons in 1 H NMR spectra of analogous derivatives . This resemblance also indicates a diastereoselective formation of one diastereoisomer of 1,5‐benzothiazepines ( 5a – t ) as the sole isolable product.…”

BIOCHEMICAL CHARACTERIZATION OF VOLATILE SECONDARY METABOLITES PRODUCED BY Burkholderia gladioli pv. agaricicola

“…On the other hand, Hossain, et al [16] have characterized the bioactivity of the extracted essential oils of Orthosiphon stamineus which has showed a remarkable antifungal effect against some phytopathogenic fungi due to the presence of caryophyllene, humulene, elemene, bourbonene, pinene, caryophyllene oxide, camphene and limonene. [17,18], antibacterial [19], antifungal [20], antiviral [21], antihypertensive [22], antioxidants [22], anti-inflammatory [22], anti-lung cancer [23] and antiviral [21] effects. Kamboj, et al [24] evaluated the antimicrobial activity of some flavanone compounds against some pathogenic bacteria and fungi and concluded that all tested flavanones exhibited antibacterial and antifungal activity against some G+ve bacteria Staphylococcus aureus and Bacillus subtilis.…”

An eco-compatible synthesis of novel spiro[acenaphthylene-1,2′[1,3]-thiazolidine]-2,4′(1H)-diones using thiamine hydrochloride as efficient catalyst in aqueous medium

“…Hence, inspired by these findings and in continuation of our ongoing work to develop environmentally benign methodologies [54][55][56][57][58][59][60][61] for the synthesis of biologically useful heterocycles, we have investigated a threecomponent protocol for the synthesis of drug-like spiro[acenaphthylene-1,2 0 [1,3]-thiazolidine]-2,4 0 (1H)-diones from the multi-component reaction of acenapthaquinone, substituted anilines, and a-mercaptoacetic acid in good yield using thiamine hydrochloride as a green, inexpensive, and reusable catalyst in aqueous medium. The present method is more convenient and efficient because it obviates the azeotropical removal of water and use of carcinogenic solvents as well as dehydrating agents.…”