Efficient Piancatelli rearrangement on a large scale using the Zippertex technology under subcritical water conditions

Abstract

Piancatelli rearrangement of furyl carbinols is a relevant reaction to produce cyclopentenone derivatives. However, on large scale, Piancatelli rearrangement suffers several serious drawbacks such as long reaction period, high dilution...

Micellar drug delivery vehicles formed from amphiphilic block copolymers bearing photo-cross-linkable cyclopentenone side groups

“…18 4CPA is a promising monomer of interest due to the scalable and renewable synthesis of its precursor 4-hydroxycyclopentenone in flow using water as the main solvent, or under supercritical water conditions. [18][19][20] Amphiphilic block copolymers based on 4CPA for drug delivery applications have not yet been produced, and are therefore an interesting subject of investigation to expand the scope of photo curable polymers in the field of self-assembly. Furthermore, the afore mentioned studies on the synthesis and self-assembly of UV curable amphiphilic block-copolymers, did not include a thorough investigation towards the effects of the individual block lengths on the amphiphilic properties, self-assembly process, and drug loading content.…”