Efficient sonochemical synthesis of novel 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

Pizzuti, Lucas; Martins, Paula Larangeira Garcia; Ribeiro, Bruna A.; Quina, Frank H.; Pinto, Ernani; Flores, Alex F. C.; Venzke, Dalila; Pereira, Cláudio M. P.

doi:10.1016/j.ultsonch.2009.06.013

Cited by 81 publications

(38 citation statements)

References 13 publications

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“…Similarly, in 2010, we reported the cyclization of chalcones (11) with aminoguanidine hydrochloride (12) under essentially the same conditions (Scheme 4) (Pizzuti et al, 2010). The 4,5-dihydropyrazole derivatives (13) were obtained in high yields in 30 minutes employing sonication.…”

Section: Azoles With Two Heteroatomsmentioning

confidence: 64%

Recent Advances in the Ultrasound-Assisted Synthesis of Azoles

Pizzuti¹,

Franco²,

Flores³

et al. 2012

Green Chemistry - Environmentally Benign Approaches

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Section: Azoles With Two Heteroatomsmentioning

confidence: 64%

Recent Advances in the Ultrasound-Assisted Synthesis of Azoles

Pizzuti¹,

Franco²,

Flores³

et al. 2012

Green Chemistry - Environmentally Benign Approaches

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“…We have prepared several classes of organic compounds by sonocatalysis Pizzuti et al, 2010;Silva et al, 2009;Venzke et al, 2011). In particular, the beneficial effects of ultrasonic irradiation are playing an increasing role in chemical processes, especially in cases where classical methods require drastic conditions or prolonged reaction times, as biodiesel synthesis.…”

Section: Resultsmentioning

confidence: 99%

Cultivation of algae in photobioreator and obtention of biodiesel

Hobuss¹,

Rosales²,

Venzke³

et al. 2011

Rev. bras. farmacogn.

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“…The 99m Tc-MIBI has also been recommended to assess the tumor size and the treatment efficiency of tumors of breast (Vecchio and Salvatore, 2004), parathyroid (Spanu et al, 2004) and lung (Dirlik et al, 2002).Ultrasound irradiation technique is routinely used in the different branches of chemistry. The reactions are carried out in order to obtain higher yields, shorter time or milder conditions under ultrasound irradiation modality (Khalaj et al, 2006;Khalaj et al, 2009 ;Pizzuti et al, 2010). In our previous study, 37 MBq (1mCi) 99m Tc-MIBI radiopharmaceutical samples with appropriate yields could be reconstituted under ultrasound irradiation technique (Doroudi et al, 2013).Thereafter, the bio-distribution of 99m Tc-MIBI complex samples were studied in the rat.…”

Section: Introductionmentioning

confidence: 99%

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

Doroudi¹,

Saraji²,

Erfani³

et al. 2016

J App Pharm Sci

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Objectives:The main propose of this investigation is to evaluate the value of ultrasound irradiation technique versus boiling water bath in the reconstitution cold MIBI (Sestamibi) kits by technetium 99m. Material and Methods: Twenty Sestamibi cold kits from various batches have been chosen. The vials were randomly divided into two equal groups. The first group was reconstituted by boiling water bath as standard method and the other group reconstituted by new developed technique. The stability of radio-complex samples were examined by thin layer chromatography (ITLC) and Radio high pressure liquid chromatography (Radio-HPLC) up to 24 hours post reconstitution. The partition coefficient and protein bonding of radiotracer samples were analyzed. Results: The significant differences have not been observed in the yields and stability of radiotracer samples which were prepared by either two methods in ITLC and Radio-HPLC investigations. The partition coefficient and protein bonding assays demonstrated that radiotracer samples which were prepared by boiling water bath were a little more lipophilic than the radio-complex samples which were reconstituted by new developed technique. Conclusion: Green chemistry is convenient and efficient modality to reconstitute the cold Sestamibi kit by technetium 99m. It can be established as an alternative method to prepared 99m Tc-Sestamibi in the clinical practice.

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Efficient sonochemical synthesis of novel 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides

Abstract: An ultrasound-assisted preparation of a series of novel 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carboximidamides that proceeds via the efficient reaction of chalcones with aminoguanidine hydrochloride under clean conditions is described.

Cited by 81 publications

References 13 publications

Recent Advances in the Ultrasound-Assisted Synthesis of Azoles

Recent Advances in the Ultrasound-Assisted Synthesis of Azoles

Cultivation of algae in photobioreator and obtention of biodiesel

The stability of 99mTc-MIBI (Sestamibi) complex samples which prepared under ultrasound irradiation technique versus boiling water bath method

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