Efficient synthesis of N-substituted-N'-arylcarbonylthioureas under solvent-free conditions

Microwave Assisted, One Pot Synthesis of Alkyl-3-amino-2-arylimino-1,3-thiazolan-4-ones-5-ylidene Acetate

“…In our continuous approach toward developing biologically active heterocyclic synthesis via acetylenic esters-based reactions involving CH-, NH-or OH-acid compounds [30][31][32][33][34] , herein we wish to explain an expedient method for construction of some novel 2-imino-thiazolidine-4-one-5-ylidene acetate derivatives (3) from one-pot reaction between 4-phenylthiosemicarbazide (1a) and thiosemicarbazide (1b) with appropriate acetylenic esters (2) in good yields (Scheme-I).…”

“…Some thiazoline-4-ones derivatives are reported as human immunodeficiency virus-1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs) or anticancer activities and can inhibit cell division . In view of the various physiological activities of thiazolidinones, many thiazolidinone derivatives have been prepared and several new methods for the preparation of substituted thiazolidine-4-one have been recently reported [31][32][33][34] . However,these methods have several drawbacks, namely, the need for a high reaction temperature and long reaction time.…”

A simple and efficient synthesis of some novel thiazolidine‐4‐one derivatives

“…Some thiazoline derivatives show interesting anti-HIV or anticancer activities and can inhibit cell division [5][6][7][8][9][10]. Because of the various physiological activities of thiazolidinones, many thiazolidinone derivatives have been prepared and several new methods for the preparation of substituted thiazolidine-4-one have been recently reported [11,12]. Despite the synthetic importance of these methods, they commonly suffer from the need to elevated temperatures and also from long reaction times.…”

Hydrogen bonding interactions in two isomers of fluorobenzoylthioureas and their absorption spectra

“…FBTT2 has been synthesized by Yavari et al under solvent-free conditions [44], however, the crystal structures and the electronic spectra of both FBTTs have not been reported. In order to investigate the effects of intra-and intermolecular hydrogen bonds on the photo-physical properties of FBTTs, both FBTT2 and FBTT4 were prepared and structurally and photo-physically characterized.…”