Efficient Synthesis of New Fused Thiadiazines and Their Spectroscopic, In Silico Drug Likeness, and ADME Properties

Alshubramy, Maha A.; Asem, M.; Abdel‐Motaal, Marwa

doi:10.1134/s1070428022040224

Russ J Org Chem

2022

DOI: 10.1134/s1070428022040224

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Efficient Synthesis of New Fused Thiadiazines and Their Spectroscopic, In Silico Drug Likeness, and ADME Properties

Maha A. Alshubramy

M. Asem²,

Marwa Abdel‐Motaal

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2024

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Cited by 2 publications

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Metal‐ and Additive‐Free One‐Pot Synthesis of 2,3,5‐Trisubstituted 1,3,4‐Thiadiazines Using β‐Ketodithioesters and 2‐Bromohydrazones through a Cross‐Coupling/Cyclization Cascade

Singh,

Shukla

et al. 2024

Eur J Org Chem

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Privileged 2,3,5‐trisubstituted 1,3,4‐thiadiazines were synthesized from readily accessible β‐ketodithioesters as a two‐atom (CS) synthon and 2‐bromohydrazones as a four‐atom (CCNN) unit through a cross‐coupling/cyclization cascade. The operationally simple metal‐ and additive‐free method shows broad substrate scope as well as high functional‐group tolerance and provides a direct route to functionalized 1,3,4‐thiadiazines that are not easily prepared by other methods. This one‐pot approach features easy‐to‐handle nontoxic reagents, high yields, gram scalability, excellent selectivity and the formation of an exocyclic double bond with Z‐stereoselectivity.

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Metal‐ and Additive‐Free One‐Pot Synthesis of 2,3,5‐Trisubstituted 1,3,4‐Thiadiazines Using β‐Ketodithioesters and 2‐Bromohydrazones through a Cross‐Coupling/Cyclization Cascade

Singh,

Shukla

et al. 2024

Eur J Org Chem

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Spectroscopic and theoretical study of novel copper(II) complexes based on phenothiazine ligands: UV–Visible absorption and photoinduced electron transfer

Abdel-Motaal,

Tar,

Messaoudi

et al. 2024

Journal of Photochemistry and Photobiology A: Chemistry

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Efficient Synthesis of New Fused Thiadiazines and Their Spectroscopic, In Silico Drug Likeness, and ADME Properties

Cited by 2 publications

References 33 publications

Metal‐ and Additive‐Free One‐Pot Synthesis of 2,3,5‐Trisubstituted 1,3,4‐Thiadiazines Using β‐Ketodithioesters and 2‐Bromohydrazones through a Cross‐Coupling/Cyclization Cascade

Metal‐ and Additive‐Free One‐Pot Synthesis of 2,3,5‐Trisubstituted 1,3,4‐Thiadiazines Using β‐Ketodithioesters and 2‐Bromohydrazones through a Cross‐Coupling/Cyclization Cascade

Spectroscopic and theoretical study of novel copper(II) complexes based on phenothiazine ligands: UV–Visible absorption and photoinduced electron transfer

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