Eficácia Anti-Helmíntica Da Ivermectina Em Equinos: Exames Coproparasitológicos E Hematológicos

Abstract

ResumoO objetivo do presente estudo foi avaliar a eficácia da ivermectina a 2% em equinos, através de exames coproparasitológicos e hematológicos. O experimento foi realizado em uma fazenda no município de Uberlândia, MG. Foram utilizados 24 equinos, de três a oito anos, divididos em dois grupos, conforme valores dos OPG. Contagens de OPG e coproculturas foram realizadas nos dias D0, D+7 e D+14. Os animais foram tratados com a formulação pasta a base de ivermectina 2%, na dose de 200 mcg/kg, via oral. Amostras de sangue foram coletadas nos dias D0, D+7 e D+14 para avaliação dos parâmetros hematológicos. A presença de ovos, característicos da família Strongylidae e identificação de larvas características de ciatostomíneos demonstrou o parasitismo dos animais por pequenos estrôngilos. Nos D+7 e D+14 houve a redução significativa do OPG no grupo tratado com eficácia de 99,5 e 99,7%, respectivamente. Observou-se tendência do quadro eritrocitário manter-se próximo aos limites inferiores e discreta leucocitose com neutrófilos próximos dos valores superiores. Pode-se inferir que a ivermectina é eficaz contra os ciatostomíneos e alterações hematológicas significativas não foram observadas. Palavras-chave: ciatostomíneos; equinos; nematódeos; OPG. AbstractThe aim of the present study was to evaluate the efficacy of ivermectin at 2% in horses, through coproparasitological and hematological exams. The experiment was performed at a farm in the city of Uberlândia, Minas Gerais State. Twenty-four horses were used, ranging from 3 to 8 years of age, divided into 2 groups according to EPG values. EPG counts and coprocultures were performed on days D0, D+7 and D+14. The animals were treated with the ivermectin 2%-based paste formulation at a dose of 200 mcg/kg, orally. Blood samples were collected on days D0, D+7 and D+14 for evaluation of haematological parameters. The presence of eggs that are characteristic of the Strongylidae family and the identification of larvae that are characteristic of cyathostomins demonstrated the parasitism of the animals by small strongyles. At D+7 and D+14 there was a significant reduction of EPG in the treated group with an efficacy of 99.5 and 99.7%, respectively. A

Anthelmintic resistance in Creole horses in the South of Rio Grande do Sul, Brazil

“…Godeski et al (2017) evaluated Moxidectin efficacy after 14 days of treatment with a reduction of 100%. Among drugs used to control parasites in horses, this is the only one with some action against encysted cyathostominaes, currently recommended for controlling this group with high efficacy rates (Barbosa et al, 2018). However, reduced efficacy of Moxidectin against cyathostominaes has already been reported in Brazil (Canever, 2012) like our result (81% in property "12").…”

Survey on sanitary practices and knowledge about infectious diseases among equine owners in the State of Rio Grande do Norte, Brazil

“…In recent decades, the indiscriminate use of these drugs has contributed to the emergence of anthelmintic-resistant nematode populations, especially those belonging to the subfamily Cyathostominae, commonly known as cyathostomines. This seriously threatens health, well-being, and equine production in several areas across the world ( Barbosa et al, 2018 ). The data from this study showed that the interviewed parents almost exclusively used anthelmintics from the macrocyclic lactone group, notably ivermectin.…”