2017
DOI: 10.1371/journal.pgen.1006882
|View full text |Cite
|
Sign up to set email alerts
|

EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation

Abstract: Development is governed by a few conserved signalling pathways. Amongst them, the EGFR pathway is used reiteratively for organ and tissue formation, and when dysregulated can lead to cancer and metastasis. Given its relevance, identifying its downstream molecular machinery and understanding how it instructs cellular changes is crucial. Here we approach this issue in the respiratory system of Drosophila. We identify a new role for EGFR restricting the elongation of the tracheal Dorsal Trunk. We find that EGFR r… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

6
24
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
3
2
1

Relationship

1
5

Authors

Journals

citations
Cited by 24 publications
(30 citation statements)
references
References 70 publications
(121 reference statements)
6
24
0
Order By: Relevance
“…Altogether our results are consistent with a model where the turnover of Crb protein is higher at LCJs. As we had previously described an endocyticrecycling turnover of Crb operating during tracheal development (20), the results suggest that Crb would be more prone to recycle and/or traffic to/at LCJs than to/at TCJs.…”
Section: Different Molecular Mechanisms Could Underlie the Preferentisupporting
confidence: 71%
See 4 more Smart Citations
“…Altogether our results are consistent with a model where the turnover of Crb protein is higher at LCJs. As we had previously described an endocyticrecycling turnover of Crb operating during tracheal development (20), the results suggest that Crb would be more prone to recycle and/or traffic to/at LCJs than to/at TCJs.…”
Section: Different Molecular Mechanisms Could Underlie the Preferentisupporting
confidence: 71%
“…Quantification of the ratio of Crb accumulation in the SAR versus the AFR in control and EGFR CA expressing tracheal cells clearly indicated a significant decrease in the mutant condition ( Fig. 4C) (20). We now extended this analysis and quantified the apical surface area.…”
Section: Src42a Promotes Crb Anisotropic Accumulationmentioning
confidence: 57%
See 3 more Smart Citations