EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C

Abstract

Interferon lambda 3 (IFNL3) and epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) may play a key role in the spontaneous clearance of hepatitis C virus (HCV) and treatment responses. The aim of this study was to evaluate the effect of IFNL3 SNPs and EGFR rs11506105 on treatment outcomes in patients with chronic HCV (CHC). IFNL3 SNPs and EGFR rs11506105 were genotyped by PCR-restriction fragment length polymorphism and PCR-sequencing, respectively, in 235 naïve patients with CHC infection. The frequency of rapid virologic response (RVR), complete early virologic response (cEVR) and sustained virologic response (SVR) were 52.3%, 76.2% and 64.7% respectively. The results of this study showed that RVR was associated with ALT (P=0.015), AST (P=0.020), IFNL3 rs12979860 (CC) (P=0.043), rs12980275 (AA) (P=1 × 10), and EGFR rs11506105 (AA) (P=0.010), and IFNL3 rs12979860 (CC) (P=0.048), rs12980275 (AA) (P=0.022), and EGFR rs11506105 (AA) (P=0.006) were correlated with cEVR. HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10), and cEVR (P=0.003) were significant predictors for SVR. These results, for the first time, revealed that beside IFNL3 SNPs, EGFR rs11506105 is strongly associated with RVR, cEVR and SVR. EGFR rs11506105 besides IFNL3 SNPs could predict treatment responses in CHC patients.

Occult hepatitis C virus infection in patients with beta‐thalassemia major: Is it a neglected and unexplained phenomenon?

“…23 According to several studies, genetic variants within IFNL3 and IFNL4 loci are correlated with the efficacy of combination therapy in CHC and spontaneous clearance. 10,11 Therefore, we tried to determine if IFNL3 SNPs and IFNL4 ss469415590 genotypes are correlated with the presence of OCI.…”

“…Aspartate aminotransferase (AST), ALT, alkaline phosphatase (ALP), fasting blood glucose (FBS), low‐density lipoprotein (LDL), cholesterol, triglyceride, high‐density lipoprotein (HDL), urea, serum creatinine, uric acid, bilirubin, white blood cells (WBC), hemoglobin, erythrocyte sedimentation rate (ESR), T3, T4, thyroid‐stimulating hormone (TSH), Luteinizing hormone (LH), and follicle‐stimulating hormone (FSH) levels were extracted from patient's records. In addition, the interferon λ3/4 ( IFNL3/4 ) gene single‐nucleotide polymorphisms (SNPs) were genotyped according to previous studies …”

First detection of human hepegivirus-1 (HHpgV-1) in Iranian patients with hemophilia

“…In addition, many cases of post-transfusion hepatitis with unknown etiology still occur among blood-transfusion recipients. However, chronic HCV infection is a major health problem and leads to liver cirrhosis, hepatocellular cancer, liver transplantation, and death 17 – 21 . In return, it was reported that most HPgV-1 infections were usually asymptomatic, transient, and self-limiting 22 .…”

The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

“…Several studies have shown that some SNPs on interferon lambda type 3 and 4 ( IFNL3/4 ) signaling are involved in the sustained antiviral response and the immunity regulation [ 7 – 9 ]. The homozygote variants of IFNL3/4 gene could be correlated with a viral clearance decrease in children affected by acute respiratory infections [ 10 ].…”