2014
DOI: 10.1371/journal.pone.0093651
|View full text |Cite
|
Sign up to set email alerts
|

EGFR Signaling Promotes β-Cell Proliferation and Survivin Expression during Pregnancy

Abstract: Placental lactogen (PL) induced serotonergic signaling is essential for gestational β-cell mass expansion. We have previously shown that intact Epidermal growth factor –receptor (EGFR) function is a crucial component of this pathway. We now explored more specifically the link between EGFR and pregnancy-induced β-cell mass compensation. Islets were isolated from wild-type and β-cell-specific EGFR-dominant negative mice (E1-DN), stimulated with PL and analyzed for β-cell proliferation and expression of genes inv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
40
1

Year Published

2015
2015
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 31 publications
(43 citation statements)
references
References 40 publications
2
40
1
Order By: Relevance
“…FOXM1, an essential factor expressed during S phase, was involved in regulation of proliferation by binding with G2/M regulators [41]. In addition, PRL-R activation could lead to transactivation of the EGF receptor, which activates MAPK and PI3K-Akt-mTOR pathways to stimulate survivin gene expression [18]. Inhibitors of the Akt, STAT5, PIM or ERK pathway significantly decreased the expression of survivin and FOXM1 in PRL-stimulated INS-1 cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…FOXM1, an essential factor expressed during S phase, was involved in regulation of proliferation by binding with G2/M regulators [41]. In addition, PRL-R activation could lead to transactivation of the EGF receptor, which activates MAPK and PI3K-Akt-mTOR pathways to stimulate survivin gene expression [18]. Inhibitors of the Akt, STAT5, PIM or ERK pathway significantly decreased the expression of survivin and FOXM1 in PRL-stimulated INS-1 cells.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, the mRNA level of survivin has been found to be elevated in gestational islets and PRL-stimulated cultured islets [17,18]. In the current study, we further explored the pattern of survivin expression in mouse maternal islets during pregnancy, finding that survivin was induced with increased nuclear localisation in response to PRL and this was associated with S and G2/M cell cycle progression via Akt, STAT5-PIM and extracellular signal-regulated kinase (ERK) signalling pathways.…”
Section: Introductionmentioning
confidence: 86%
“…Earlier, human cathelicidin LL‐37 has been mostly studied for antiapoptotic effects, on neutrophils via FPR2 and P2X 7 (28, 29), proproliferative effects on airway epithelial cells via EGFR (30), and promotes wound‐healing activities through transactivation of EGFR as well as induction of FPR2 on keratinocytes (31). In rodents, EGFR signaling plays a central role in β‐cell proliferation during islet development and compensatory β‐cell mass expansion during insulin resistance in mice (32, 33). rCRAMP induces proliferation of rat gastric epithelial cells through TGF‐α—dependent transactivation of EGFR (34).…”
Section: Discussionmentioning
confidence: 99%
“…During pregnancy, β cell mass expands in order to adapt the organism to increasing insulin demand (71)(72)(73)(74). Multiple factors, including lactogens, serotonin, and components of the EGFR signaling pathway, have been shown to increase β cell replication in pregnant rodents (71,(75)(76)(77)(78). There is, however, controversy as to whether adaptive β cell proliferation during pregnancy occurs to the same extent in humans (72).…”
Section: Introductionmentioning
confidence: 99%