Eggshell Membrane Based Turmeric Extract Loaded Orally Disintegrating
Films

Köse, Merve Deniz; Ungun, Nazlı; Bayraktar, Oğuz

doi:10.2174/1567201818666210708123449

Cited by 22 publications

(9 citation statements)

References 22 publications

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“…In contrast, shown in the right column of Figure 1 , water-insoluble and bio-degradable polymers are often exploited to prepare casting films for providing drug sustained release profiles [ 37 , 38 , 39 , 40 , 41 ]. As the polymeric carriers are insoluble in water, the loaded drug molecules must be freed into the dissolution medium through a diffusion mechanism [ 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

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Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

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“…Fast dissolution of poorly water-soluble drugs is common for many active ingredients in traditional dosage forms ( Ejeta et al, 2022 ; Köse et al, 2022 ; Assi et al, 2023 ; Yu and Huang, 2023 ). Figure 8B displays the CIP release profile from S1.…”

Section: Resultsmentioning

confidence: 99%

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Sun,

Zhou,

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Bacterial prostatitis is a challenging condition to treat with traditional dosage forms. Physicians often prescribe a variety of dosage forms with different administration methods, which fail to provide an efficient and convenient mode of drug delivery. The aim of this work was to develop a new type of hybrid material incorporating both electrosprayed core-shell microparticles and electrospun nanofibers. A traditional Chinese medicine (Ningmitai, NMT) and a Western medicine (ciprofloxacin, CIP) were co-encapsulated within this material and were designed to be released in a separately controlled manner. Utilizing polyvinylpyrrolidone (PVP) as a hydrophilic filament-forming polymer and pH-sensitive Eudragit® S100 (ES100) as the particulate polymeric matrix, a combined electrohydrodynamic atomization (EHDA) method comprising coaxial electrospraying and blending electrospinning, was used to create the hybrids in a single-step and straightforward manner. A series of characterization methods were conducted to analyze both the working process and its final products. Scanning electron microscopy and transmission electron microscopy revealed that the EHDA hybrids comprised of both CIP-PVP nanofibers and NMT-ES100 core-shell microparticles. Multiple methods confirmed the rapid release of CIP and the sustained release of NMT. The antibacterial experiments indicated that the hybrids exhibited a more potent antibacterial effect against Escherichia coli dh5α and Bacillus subtilis Wb800 than either the separate nanofibers or microparticles. The amalgamation of fibrous nanomedicine and particulate micromedicine can expand the horizon of new types of medicines. The integration of electrospinning and coaxial electrospraying provides a straightforward approach to fabrication. By combining hydrophilic soluble polymers and pH-sensitive polymers in the hybrids, we can ensure the separate sequential controlled release of CIP and NMT for a potential synergistic and convenient therapy for bacterial prostatitis.

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“…As the most attractive electrohydrodynamic atomization (EHDA) process, it is more applicable than other EHDA processes such as electrospraying and e-jet printing ( Li et al, 2023 ; Li et al, 2023 ). In the literature, electrospun drug-loaded nanofibers have been extensively investigated for their potential to resolve some key issues in pharmaceutics, such as the dissolution of poorly water-soluble drugs; the oral delivery of peptides, proteins, and vaccines; anti-drug resistance, and the effective crossing of the major human body barriers (the blood–brain barrier, the placental barrier, and the skin) for efficacious therapy ( Vass et al, 2020 ; He et al, 2021 ; Köse et al, 2021 ; Lv et al, 2021 ; Jiang et al, 2022a ; Pattnaik et al, 2022 ; Yu and Zhao, 2022 ; Yu, 2023 ). Electrospinning can allow for the possibility of new licorice commercial products.…”

Section: Introductionmentioning

confidence: 99%

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Liu

Dai

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: As an interdisciplinary field, drug delivery relies on the developments of modern science and technology. Correspondingly, how to upgrade the traditional dosage forms for a more efficacious, safer, and convenient drug delivery poses a continuous challenge to researchers.Methods, results and discussion: In this study, a proof-of-concept demonstration was conducted to convert a popular traditional liquid dosage form (a commercial oral compound solution prepared from an intermediate licorice fluidextract) into a solid dosage form. The oral commercial solution was successfully encapsulated into the core–shell nanohybrids, and the ethanol in the oral solution was removed. The SEM and TEM evaluations showed that the prepared nanofibers had linear morphologies without any discerned spindles or beads and an obvious core–shell nanostructure. The FTIR and XRD results verified that the active ingredients in the commercial solution were compatible with the polymeric matrices and were presented in the core section in an amorphous state. Three different types of methods were developed, and the fast dissolution of the electrospun core–shell nanofibers was verified.Conclusion: Coaxial electrospinning can act as a nano pharmaceutical technique to upgrade the traditional oral solution into fast-dissolving solid drug delivery films to retain the advantages of the liquid dosage forms and the solid dosage forms.

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Eggshell Membrane Based Turmeric Extract Loaded Orally Disintegrating Films

Cited by 22 publications

References 22 publications

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

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