Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields

Seong, Yeju; Moon, Jihye; Kim, Jong-Pil

doi:10.1016/j.lfs.2014.02.022

Cited by 32 publications

(18 citation statements)

References 33 publications

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“…In particular, Egr1, regarded as a strong early neurogenic transcription factor, appeared to be the most highly upregulated in neuronal differenting cultures from hBM-MSCs and mouse NSCs. Seong et al (2014) further confirmed the role of Egr1 in mediating the pro-neurogenic effect of ELFEFs on MSCs showing that: (i) knockdown of Egr1 in the hBM–MSCs significantly inhibited ELFEF induced neuronal differentiation; (ii) the overexpression of Egr1 combined with ELFEF exposure increased the efficiency of cell-replacement therapy thus alleviating neurological symptoms in a Parkinson’s disease mouse model.…”

Section: Effects Of Electromagnetic Fields On Neural and Mesenchymal mentioning

confidence: 91%

“…Similar results were obtained by Bai et al (2013) using similar ELFEF parameters (50 Hz, 5 mT for 12 days). More recently, Seong et al (2014) showed that ELFEF exposure (50 Hz, 1 mT for 8 days) of hBM-MSCs promoted neuronal differentiation even in the absence of any neurotrophic factor. Indeed, exposed hBM–MSCs showed significant increase of NeuroD1 expression as well as electrophysiological properties of neurons.…”

Section: Effects Of Electromagnetic Fields On Neural and Mesenchymal mentioning

confidence: 99%

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Impact of electromagnetic fields on stem cells: common mechanisms at the crossroad between adult neurogenesis and osteogenesis

Leone

Podda

Grassi

2015

Front. Cell. Neurosci.

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In the recent years adult neural and mesenchymal stem cells have been intensively investigated as effective resources for repair therapies. In vivo and in vitro studies have provided insights on the molecular mechanisms underlying the neurogenic and osteogenic processes in adulthood. This knowledge appears fundamental for the development of targeted strategies to manipulate stem cells. Here we review recent literature dealing with the effects of electromagnetic fields on stem cell biology that lends support to their use as a promising tool to positively influence the different steps of neurogenic and osteogenic processes. We will focus on recent studies revealing that extremely-low frequency electromagnetic fields enhance adult hippocampal neurogenesis by inducing epigenetic modifications on the regulatory sequences of genes responsible for neural stem cell proliferation and neuronal differentiation. In light of the emerging critical role played by chromatin modifications in maintaining the stemness as well as in regulating stem cell differentiation, we will also attempt to exploit epigenetic changes that can represent common targets for electromagnetic field effects on neurogenic and osteogenic processes.

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Section: Effects Of Electromagnetic Fields On Neural and Mesenchymal mentioning

confidence: 91%

Section: Effects Of Electromagnetic Fields On Neural and Mesenchymal mentioning

confidence: 99%

Impact of electromagnetic fields on stem cells: common mechanisms at the crossroad between adult neurogenesis and osteogenesis

Leone

Podda

Grassi

2015

Front. Cell. Neurosci.

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“…In situations like diabetic peripheral neuropathy the literature shows that in the PEMF area many clinical observations exist, [59,63,64]; whereas the literature is very inconsistent for in vitro studies on neuronal cells as well as for studies with molecular-and cell biological background [65][66][67][68][69][70][71][72]. On the other hand, a profound understanding of the ongoing processes, especially of potential neuroprotective effects -see also such EF effects in patients of retinal degeneration would be very useful e.g.…”

Section: Interactions Of Emf/pemf With "Classical" Cell Biology -In Vmentioning

confidence: 99%

Does electromagnetic therapy meet an equivalent counterpart within the organism?

Funk¹

2017

J Transl Sci

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This review bundles all available new information about intrinsic electrical phenomena in many types of cells (also non-neural) and tissues and shows that exogenously applied electric fields (as DC -EF, EMF or pulsed electromagnetic fields PEMF) can couple to the endogenous electrical phenomena of the body. These endogenous fields are generated ubiquitously in all tissues via cellular ion pumps and transporters and these ion gradients can be transferred by gap junctions. Such electric phenomena can now be monitored in living cells and tissues by electro-sensitive markers. Observations are now available from early embryonic development on to wound healing and regeneration within the adult organism. Based on these grounds we demonstrate that endogenous electric fields act directly on classical pathways of molecular and cell biology. Adequately applied frequencies and pulsing from outside can couple to these endogenous fields or to the receptors of classical biochemical pathways and manifest in positive "reprogramming" of tissue functions. In sum, this new analytical approach to the bodies´ own electrical information processes opens up new avenues for adequate EMF and PEMF therapy.

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“…Recent in vitro studies have suggested that exposure of human bone marrow-derived mesenchymal stem cells to ELF-EMF decreases their proliferation rate instead of causing an increase in both osteogenic and neuronal differentiation [12][13][14][15]. To explore the effects of RF-EMFs on cultured neuronal cells, the growth and differentiation of a standard neuronal-like cell line was studied.…”

Section: Effects Of 915 Mhz Radiofrequency Identification Electromagnmentioning

confidence: 99%

Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains

Kim¹,

Lee²,

Lee³

et al. 2015

Journal of electromagnetic engineering and science

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To explore the effects of radiofrequency electromagnetic field on the fate of neuronal cells, we investigated whether exposure to 915 MHz radiofrequency identification (RFID) caused morphological changes in neuronal cells in rat hippocampal dentate gyrus (DG). A reverberation chamber was used as a whole-body RFID exposure system. Rats were assigned to two groups: sham-and RFID-exposed groups. Rats in the RFID-exposed group were exposed to RFID at 4 W/kg specific absorption rate (SAR) for 8 hours daily, 5 days per week, for 2 weeks. Morphological evaluation of DG was performed using immunohistochemistry with doublecortin (DCX) as a neuronal precursor cell marker and neuronal nuclei (NeuN) as a mature neuronal cell marker. No significant morphological changes in DCX+ or NeuN+ cells in the DG of RFID-exposed rats were observed. These results suggest that RFID exposure induces no significant change in DCX+ neuronal precursor or NeuN+ neuronal cells in DG of rats.

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Egr1 mediated the neuronal differentiation induced by extremely low-frequency electromagnetic fields

Cited by 32 publications

References 33 publications

Impact of electromagnetic fields on stem cells: common mechanisms at the crossroad between adult neurogenesis and osteogenesis

Impact of electromagnetic fields on stem cells: common mechanisms at the crossroad between adult neurogenesis and osteogenesis

Does electromagnetic therapy meet an equivalent counterpart within the organism?

Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains

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