Egyptian red sea seagrass as a source of biologically active secondary metabolites

Hamdy, Abdel-Hamid A.; El-fiky, Nabaweya M.; El‐Beih, Ahmed A.; Mohammed, Magdy M. D.; Mettwally, Walaa S. A.

doi:10.4103/epj.epj_57_19

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…748 In vivo activity in a mouse peritonitis model was observed. New examples of weakly cytotoxic metabolites thalassodendron B 1506 and thalassosterol 1507 were isolated from the Red Sea seagrass Thalassodendron ciliatum, 749,750 while new diarylheptanoids 1508 and 1509 were reported from a German collection of Zostera marina. 751…”

Section: Miscellaneousmentioning

confidence: 99%

Marine natural products

et al. 2022

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Section: Miscellaneousmentioning

confidence: 99%

Marine natural products

et al. 2022

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“…The isolation of marine actinobacteria is influenced by the isolation parameters such as culture, pondus hydrogenii (pH) and temperature, incubation time, and concentration of the medium [51]. Numerous studies attest to culture seagrass-derived actinobacteria by employing the cultivation parameters as follows: using a wide variety of media, the addition of natural seawater, artificial seawater, or deionized/ distilled water with different concentrations of sodium chloride, culture temperature 26°-29°C, and an incubation time of 1-6 weeks [52][53][54][55][56][57]. Certain actinobacterial have been isolated from all seagrass parts (roots, rhizomes, and leaves), whereas, most research specifically targeted actinobacteria as endophytes from the roots and leaves of seagrass, as shown in Table 1.…”

Section: Diversity and Bioactive Profiles Of Seagrass-derived Actinob...mentioning

confidence: 99%

“…At the time of this review, there were no purified molecules derived from seagrassassociated actinobacteria that were subjected to structure elucidation. Studies have shown that they have a spectrum of biological potentials such as antibacterial activity [52,53,57,71,72], antifungal activity [55,71], algicidal activity [73], nitrogen-fixing ability, and enzymatic activity [54]. Conspicuously, there are available studies where no bioactive test was performed for the actinobacteria discovered [56,74].…”

Section: Diversity and Bioactive Profiles Of Seagrass-derived Actinob...mentioning

confidence: 99%

Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses

Siro,

Pipite

2024

Explor Drug Sci

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The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage are derived from microbial metabolites, especially those belonging to the bacterial group, actinobacteria. Actinobacteria are hotspot organisms that exist in all habitats with a myriad of unique biosynthetic metabolites. Seagrasses appear to be a key ecosystem within the coastal environment worth bioprospecting for novel natural products. Unfortunately, literature about the bioactive potential of their associated prokaryotes, including actinobacteria remains limited. In this context, this review focused on actinobacteria with antibiotic-producing capabilities derived from different parts of seagrass plants (i.e. roots, rhizomes, and leaves). To date, there were no purified molecules derived from seagrass-associated actinobacteria that were subjected to structure elucidation. From the underpinning of numerous biological profiles such as antibacterial, antifungal, and algicidal activities of seagrass-derived actinobacteria reported in this review during the period from 2012–2020, it provides a continual growth of knowledge accruing overtime, providing a foundation for future research.

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“…Additionally, they are a rich source of secondary metabolites such as phenolics, alkaloids, flavonoids, terpenes and each of these classes is comprised of thousands of different individual compounds and possesses a variety of biological activities such as anticancer, antibacterial, antibacterial anti-inflammatory, antifungal, and antioxidant, as well as their nutritional values. (Kannan et al, 2012;Baehaki et al, 2016;Hamdy et al, 2020;Parthasarathi et al, 2021;Kim et al, 2021) Several study papers on different aspects of the physiology of halophytes have been published (Shabala 2013, Yin et al, 2019, and Yuan et al, 2019, including ecology and evolution (Lastiri-Hernández et al, 2020), biochemistry, and molecular biology (Rozentsvet et al, 2017). They are fascinating plants because they live and develop in harsh environments with high salt content.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Anticancer Activities of Some Terrestrial and Aquatic Plants Growing in Saline Habitats.

Ahmed,

El-Saied,

Salah El Din

et al. 2024

Al-Azhar Journal of Agricultural Research

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Halophytes are plants with significant economic potential for their nutritional and medicinal properties. High-performance liquid chromatography (HPLC) was used to identify the phenolics and flavonoids compounds of six halophyte plants (Spergularia marina, Suaeda aegyptiaca, Arthrocnemum fruticosum, Halophila stipulacea, Halodule uninervis, and Thalassodendron ciliatum) ethanol extracts, additionally, physiochemical parameters such as total ash, water-soluble ash acid in soluble ash, total carbohydrates, soluble carbohydrates, total nitrogen, and total protein were estimated. The results showed that nineteen phenolic and eleven flavonoid compounds were confirmed by HPLC qualitatively and quantitatively in ethanol extracts of all plants. The major compounds were chlorogenic, gallic, vanillic, naringin, and naringenin. Also, evaluation of their anticancer activities against cell lines such as pancreatic carcinoma (PA1), lung cancer (A549), prostate cancer (PC3), and colon cancer (Caco2) was carried out. The anticancer activities of A. fruticosum site (1), S. marina, and A. fruticosum site (2) extracts demonstrated the highest effective anticancer activities with IC50 values of 74.38 ± 3.04, 85 ± 2.11, and 88.922 ± 0.735 µg/mL, respectively, against human cancer cell lines (caco2) than other plants that were understudied. As a result of this research, halophyte plants can be viewed as a potential medicinal ingredient.

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Egyptian red sea seagrass as a source of biologically active secondary metabolites

Cited by 9 publications

References 6 publications

Marine natural products

Marine natural products

Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses

Phytochemical Screening and Anticancer Activities of Some Terrestrial and Aquatic Plants Growing in Saline Habitats.

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