Eicosanoids and airway smooth muscle

Gardiner, P.J.

doi:10.1016/0163-7258(89)90090-9

Cited by 19 publications

(2 citation statements)

References 197 publications

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“…All the contractive prostaglandins and thromboxanes react via an apparent single thromboxane (TP) A2 receptor (49,50). Other TP receptor subtypes may exist, which could explain why the TP receptor is not very selective; however, strong evidence supports the existence of a single form of the TP receptor in both platelets and smooth muscle cells (5).…”

Section: Resultsmentioning

confidence: 99%

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma.

Øie¹,

Hersoug²,

Madsen³

1997

Environ Health Perspect

211

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Section: Resultsmentioning

confidence: 99%

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma.

Øie¹,

Hersoug²,

Madsen³

1997

Environ Health Perspect

211

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“…Guinea pigs have been used in experimental models for asthma, since their airway reactivities to bron choconstrictors and the mediators released in allergic reactions are similar to those found in asthmatic patients (17,18). Slow reacting sub stance of anaphylaxis (SRS-A), which consists of peptide-LTs, is an important mediator of pulmonary anaphylaxis in humans and guinea pigs (19). In sensitized guinea pigs pretreated with indomethacin, pyrilamine and proprano lol, antigen challenge causes slowly developing and sustained bronchoconstriction indicative of a SRS-A response.…”

Section: Discussionmentioning

confidence: 99%

Reversing Effect of Anti-Asthmatic Drugs on Bronchoconstriction Induced by Antigen Challenge and Histamine in Anesthetized Guinea Pigs.

et al. 1992

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We performed an in vivo evaluation of bronchodilation using a model of antigen-induced bronchoconstriction in anesthetized guinea pigs pretreated with in domethacin, pyrilamine and propranolol, and the results were compared with those for the histamine-induced response. Test drugs were administered intravenously when the antigen or histamine response reached its peak. Leukotriene (LT) D4 antagonists, FPL55712 and LY171883, gradually reduced the antigen-induced response, whereas the lipoxygenase inhibitor phenidone had no such effect. The bronchodilator theophylline rapidly reduced the antigen-induced response, and the adenylate cyclase activator forskolin had a similar effect. The following drugs also had no effect: nifedi pine (calcium-channel antagonist), cromakalim (potassium-channel opener), amlex anox and disodium cromoglycate: DSCG (anti-allergic drugs), OKY-046 (thrombox ane A2 synthetase inhibitor), and dapsone (anti-inflammatory drug). Theophylline, the beta-adrenoceptor agonist salbutamol and the histamine H1-blocker pyrilamine had only a small reversing effect on histamine-induced bronchoconstriction. These re sults suggest that antigen-, but not histamine-, induced bronchoconstriction in anesthe tized guinea pigs is a useful in vivo model for evaluating the bronchodilating effect of anti-asthmatic drugs.Bronchodilators, theophylline and beta adrenoceptor agonists are widely used in the therapy of asthma (1, 2). Theophylline inhibits antigen and agonists-induced bronchospasm in guinea pigs (3, 4), and it also has an anti allergic effect in rats (5, 6). Similarly, beta adrenoceptor agonists, salbutamol and iso proterenol, and the adenylate cyclase activator forskolin have anti-asthmatic and anti-allergic activity (7,8). Calcium-channel antagonists (9, 10) and potassium channel openers (11-13) also exhibit bronchodilating effects in the guinea pig, and anti-allergic drugs, DSCG and amlexanox (14), and the TXA2 synthetase in hibitor OKY-046 (15) inhibit antigen-induced bronchospasm in the guinea pig. However, the bronchodilating effect of these drugs on bron choconstriction in vivo have not been investi gated in detail.The purpose of the present study was to de velop an in vivo system for examining the bronchodilating effect of anti-asthmatic drugs. Therefore, we examined the reversing effects of anti-asthmatic drugs on antigen-induced bronchoconstriction in anesthetized guinea pigs, because antigen causes slowly developing and sustained bronchoconstriction in sensitized guinea pigs pretreated with indomethacin,

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The Role of Eicosanoids in Inflammation and Allergy

Jonsson¹,

Dahlén²

1999

Prostaglandins, Laukotrienes and Other Eicosanoids

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Eicosanoids and airway smooth muscle

Cited by 19 publications

References 197 publications

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma.

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma.

Reversing Effect of Anti-Asthmatic Drugs on Bronchoconstriction Induced by Antigen Challenge and Histamine in Anesthetized Guinea Pigs.

The Role of Eicosanoids in Inflammation and Allergy

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