Eikenella corrodens Infective Endocarditis in a Previously Healthy Non-Drug User

Watkin, Richard; Baker, Nicky; Lang, Sue; Ment, Jerome

doi:10.1007/s10096-002-0846-6

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…Even though it is for some time obvious that periodontal pathogens can enter the circulation, causing transient bacteraemia, there were no systematic assessments of potential association between oral bacteria and extraoral infections. Although Eikenella species, for instance, have been shown to cause endocarditis and intraabdominal infection, they are considered a very rare etiological agent (Danzinger et al, 1994;Watkin et al, 2002). Interestingly, we found E. corrodens in three cases of acute necrotizing pancreatitis.…”

Section: Resultsmentioning

confidence: 53%

Inflammatory Diseases - A Modern Perspective

Nagal¹

2011

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Section: Resultsmentioning

confidence: 53%

Inflammatory Diseases - A Modern Perspective

Nagal¹

2011

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“…The liver abscess is the largest ever described caused by this bacteria. Reviewing the literature revealed only 12 previous case reports of Eikenella corrodens liver abscess [ 6 – 17 ] and 18 cases of endocarditis [ 5 , 20 – 37 ]. The opportunistic pathogen Eikenella corrodens is one of the HACEK bacteria and constitute part of the normal human mucosal flora, predominantly the oropharynx [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…HACEK bacteria have traditionally been associated with endocarditis and causes approximately 3% of all infective endocarditis [ 3 ], but blood cultures are frequently sterile in HACEK endocarditis cases [ 4 ]. Eikenella corrodens is the least common cause of HACEK endocarditis and it has only been sporadically described in the literature and often in patients with risk factors [ 4 ]; in particular recent dental therapy, intravenous drug abuse, immunosuppression or valvular damage [ 5 ]. In the 1970ies it was discovered that Eikenella corrodens could cause visceral abscesses including liver abscesses [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report

et al. 2018

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BackgroundEikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male.Case presentationA 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests. Initially pneumonia was suspected, but due to lack of improvement on pneumonia treatment, a PET-CT scan was performed, which showed a large multiloculated abscess in the liver. The abscess was drained using ultrasound guidance. Culture demonstrated Eikenella corrodens. Transesophageal echocardiography revealed aortic endocarditis. The patient was treated with antibiotics and abscess drainage, on which he slowly improved. He was discharged after 1.5 months of hospitalisation. On follow-up 2 months later, the patient was asymptomatic with normalized biochemistry and ultrasound showed complete regression of the abscess.ConclusionsThis is the first case of documented Eikenella corrodens concurrent liver abscess and endocarditis. The case report highlights that Eikenella corrodens should be considered as a cause of liver abscess. Empirical treatment of pyogenic liver abscess will most often cover Eikenella corrodens, but the recommended treatment is a third generation cephalosporin or a fluoroquinolon. A multiloculated liver abscess may require drainage several times during treatment. The finding of Eikenella corrodens should elicit an echocardiography to diagnose endocarditis even in patients without clinical signs of endocarditis.

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“…Infections caused by bacteria of the HACEK group should be suspected in patients with history of periodontal disease or recent dental treatment 1,4 .…”

Section: Discussionmentioning

confidence: 99%

“…They have the following similar clinical and microbiological properties: are Gram-negative bacilli, more easily isolated in aerobic media; their cultures require prolonged incubation time for growing (mean, 3.3 days); and may be considered part of normal flora of the upper respiratory tract and oropharynx 1,2 . The following characteristics have been identified in endocarditis caused by the HACEK microorganisms: insidious clinical findings 1 ; difficult diagnosis due to the fastidious nature of the microorganisms; and negative cultures 3,4 .…”

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confidence: 99%

Endocardite infecciosa causada por Eikenella corrodens

Cardoso¹,

Ochiai

Oliveira

et al. 2005

Arq. Bras. Cardiol.

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The HACEK microorganisms (Haemophilus spp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) account for 3% of the cases of endocarditis. They have the following similar clinical and microbiological properties: are Gram-negative bacilli, more easily isolated in aerobic media; their cultures require prolonged incubation time for growing (mean, 3.3 days); and may be considered part of normal flora of upper respiratory tract and oropharynx. The following characteristics have been identified in endocarditis caused by the HACEK microorganisms: insidious clinical findings; difficult diagnosis due to the fastidious nature of the microorganisms; and negative cultures. The Eikenella corrodens endocarditis was first described in 1972. That microorganism continues to be a rare etiological agent. We report the case of a female patient with native valve, who had Eikenella corrodens infective endocarditis.

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Eikenella corrodens Infective Endocarditis in a Previously Healthy Non-Drug User

Cited by 10 publications

References 11 publications

Inflammatory Diseases - A Modern Perspective

Inflammatory Diseases - A Modern Perspective

Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report

Endocardite infecciosa causada por Eikenella corrodens

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