Ein Beitrag zu der feineren Structur und dem Chemismus der Nebennieren

Arnold, Julius

doi:10.1007/bf01979887

Cited by 109 publications

(32 citation statements)

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“…In the literature, Arnold recorded the earliest documented case of adrenal myelolipoma as 'adrenal lipoma' in German literature in 1866 (Arnold 1866). Then, Edgar von Gierke, a German pathologist, reported the fatty component and myeloid component in 1905 (Gierke 1905).…”

Section: Myelolipomamentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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Adrenal lipomatous tumour is a group of adrenal tumours with a significant component of adipose tissue. According to the current World Health Organization (WHO) classification of tumours of endocrine organs, adrenal myelolipoma is the only entity amongst the group of tumours being described. In the literature, other more recently documented adrenal lipomatous tumours included 24 lipomas, 32 teratomas and 16 angiomyolipomas. Rare fatty tumours of the adrenal gland comprised liposarcoma, hibernoma, adrenocortical tumours with fat component and rare adrenal tumours with fat component. Myelolipoma comprises approximately 3% of primary adrenal tumour. It is noted more commonly in females and in the right adrenal gland. Approximately 40 bilateral myelolipomas were reported. The tumour is most frequently recorded in patients between fifth and seventh decades of life. Adrenal lipomas are often seen in males and in the right adrenal gland. They were commonly noted in patients in the sixth decade of life. The diagnosis could only be possible on examination of the surgically removed specimen. Adrenal teratomas were more common in females and with a bimodal age distribution. Slightly over 60% of the patients with adrenal teratoma are symptomatic. Adrenal angiomyolipomas were often symptomatic, more common in females and in the fifth decades of life. To conclude, adrenal lipomatous tumour is uncommon. They are often benign and non-functional. It is important to recognize the features of this group of lipomatous tumours in the adrenal gland as they are being detected on increasing incidence as a result of the wide-spread use of modern imaging modalities.

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Section: Myelolipomamentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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“…4 Histology of the mammalian adrenal cortex was originally described in 1866. 5 The ZG is the outer layer of the cortex adjacent to the capsule composed of small and clear cells. In rodents, 5 to 10 cell layers (Ϸ50 m) form a continuous zone 6,7 ; in humans, in contrast, the ZG is discontinuous.…”

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confidence: 99%

Adrenal Cortex Remodeling and Functional Zona Glomerulosa Hyperplasia in Primary Aldosteronism

et al. 2010

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Abstract-Primary aldosteronism is the most common form of secondary hypertension with hypokalemia and suppressed renin-angiotensin system caused by autonomous aldosterone production. Our aim was to compare zona glomerulosa (ZG) structure and function between control adrenals and the peritumoral tissue from patients operated on for aldosterone-producing adenoma. ZG morphology and CYP11B1, CYP11B2, and disabled 2 expression were studied in 15 control adrenals and 25 adrenals with aldosterone-producing adenoma. A transcriptome analysis was done using publicly available data sets. In control adrenals, ZG was discontinuous, and CYP11B2 expression was focal or partly continuous and localized to 3 structures, foci, megafoci, and aldosterone-producing cell clusters. CYP11B2 expression was restricted to a limited number of ZG cells expressing Dab2 but not CYP11B1; aldosterone-producing cell clusters were composed of cells with an intermediate phenotype expressing CYP11B2 but not disabled 2 or CYP11B1. In peritumoral tissue, large remodeling of the adrenal cortex was observed with increased nodulation and decreased vascularization that were not correlated with CYP11B2 expression. In 17 out of 25 adrenals, hyperplasia of adjacent ZG was observed with persistent expression of CYP11B2 that was extended to the entire ZG. In all of the adrenals from patients with aldosterone-producing adenoma, CYP11B2 expression was present in foci, megafoci, and aldosteroneproducing cell clusters. Transcriptome profiling indicates a close relationship between peritumoral and control adrenal cortex. In conclusion, adrenal cortex remodeling, reduced vascularization, and ZG hyperplasia are major features of adrenals with aldosterone-producing adenoma. Transcriptional phenotyping is not in favor of this being an intermediate step toward the formation of aldosterone-producing adenoma. (Hypertension. 2010;56:885-892.)Key Words: zona glomerulosa hyperplasia Ⅲ aldosterone-producing adenoma Ⅲ secondary hypertension Ⅲ adrenal cortex remodeling Ⅲ aldosterone Ⅲ potassium Ⅲ transcriptome P rimary aldosteronism (PAL) is the most common form of endocrine hypertension with a prevalence of 7% to 10% of hypertensive patients. 1 In PAL, autonomous production of aldosterone is associated with suppressed renin activity, hypokalemia, and hypertension. The two principal forms are unilateral aldosterone-producing adenoma (APA), a benign tumor of the adrenal cortex, and bilateral adrenal hyperplasia, also known as idiopathic hyperaldosteronism. Whereas in APA the adjacent zona glomerulosa (ZG) is believed to be nonfunctional because of negative feedback regulation, bilateral adrenal hyperplasia involves the entire ZG of both adrenal glands. 2 Patients with PAL operated on the basis of an APA, and/or a lateralized aldosterone hypersecretion can be cured by unilateral adrenalectomy. However, only Ϸ70% of patients with lateralized aldosterone secretion are cured by surgery, 3 suggesting that, in some cases, residual aldosterone secretion from the contralateral adrenal g...

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“…The cortex contains three histologically distinct zones, outmost the "zona glomerulosa", followed by the "zona fasciculata", and the "zona reticularis" directly surrounding the medulla (1). These zones play distinct roles in steroid hormone production (19).…”

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confidence: 99%

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment

Bielohuby

Herbach²,

Wanke³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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The adrenal gland is of critical importance for a plethora of biological processes. We performed the first systematic analysis of adrenal gland growth using unbiased stereological methods in male and female mice from weaning to adulthood ( weeks 3, 5, 7, 9, and 11) at the organ, compartment, and cellular levels. Adrenal weights increased from week 3 to week 7 in male and female mice, remained at this level in females, but decreased by 25% between week 7 and week 9 in males. Female adrenal glands displayed a higher weight at any stage investigated. The volume of the zona fasciculata was consistently higher in female vs. male mice. In both genders, the number of zona fasciculata cells reached a maximum at the age of 7 wk and decreased significantly until week 9. Serum corticosterone concentrations decreased from 3 to 11 wk of age both in male and female mice. However, the estimated total amounts of corticosterone in the circulation were similar in 3- and 11-wk-old mice. Furthermore, total circulating corticosterone was higher in females than in males at an age of 5 and 11 wk. In the zona glomerulosa and in the X-zone, time- and gender-dependent growth effects were observed. In conclusion, our results demonstrate that growth and function of the adrenal glands are markedly influenced by gender and age. These factors require careful consideration in studies aiming at the functional dissection of genetic and environmental factors affecting adrenal growth and function.

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Ein Beitrag zu der feineren Structur und dem Chemismus der Nebennieren

Cited by 109 publications

References 0 publications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Adrenal Cortex Remodeling and Functional Zona Glomerulosa Hyperplasia in Primary Aldosteronism

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment

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