Ein individueller Silikonstrahlenapplikator für die nasopharyngeale Brachytherapie

Schick, Bernhard; Weiss, Rita; Niewald, Marcus; Schneider, Mathias

doi:10.1055/s-2004-814468

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…Brachytherapy allows the application of radiation doses with high precision and accuracy in a short period of time and minimizes the frequency of complications for the adjacent healthy tissue [9,10], expanding so the role of radiotherapy in the sensitive area of head region [8]. None of The difficult exposition of tumours of the sinonasal tract and nasopharynx in combination with the frequent inability to achieve a resection with removal of extended surrounding healthy tissue in the situation of advanced tumour disease resulting in generally poor prognosis of these patients has attracted the attention of the head and neck surgeons to brachytherapy [11].…”

Section: Discussionmentioning

confidence: 99%

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Customized individual applicators for endocavitary brachytherapy in patients with cancers of the nasal cavity, sinonasal region and nasopharynx

Kadah

Niewald

Papaspyrou

et al. 2015

Eur Arch Otorhinolaryngol

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Brachytherapy has become an established therapeutic regimen for primary, persistent, recurrent and metastatic tumour disease in the head and neck region. This study presents the authors' preliminary experience with intracavitary brachytherapy by means of an individual silicone applicator in the treatment of patients with nasal, sinonasal, orbital and nasopharyngeal cancer. Between January 2001 and January 2013, twenty patients with cancer of the nasal cavity, the paranasal sinuses and nasopharynx underwent surgery and intracavitary brachytherapy with the aid of an individually manufactured silicone applicator in the Department of Otolaryngology, Head and Neck Surgery and in the Department of Radiotherapy and Radiooncology at the Saarland University Medical Center of Homburg, Germany. The tumour was localized in the nasal cavity/paranasal sinuses (15) affecting the orbit twice and the nasopharynx (5). There were 14 patients with squamous cell carcinoma, 2 patients with mixed tumours and one patient with adenocarcinoma, adenoid cystic carcinoma, mucosal melanoma or plasmocytoma. The majority of the patients presented with advanced disease (T3 or T4 tumours). In 18/20 patients, brachytherapy was performed as a boost technique, in the remaining two solely because of a previous radiation series. All surgical interventions were performed endonasally. Three to six weeks after surgery, a cast of the nasal cavity was created under general anaesthesia. Subsequently, an individual brachytherapy silicon applicator with two to four plastic tubes was manufactured. The radiation therapy was applied using the Ir-192 high-dose-rate-afterloading method (total dose 10-20 Gy) in two to five sessions, additionally in 18/20 patients a percutaneous radiotherapy with a total dose of 30-60 Gy was applied. After a mean duration of follow-up of 2 years, 7/20 patients experienced a local progression, 5/19 a regional recurrence in the neck nodes and 4/19 distant metastases. The 2-year survival was 57.3 %. No serious complications were reported. The silicone applicator was well tolerated by all patients. Because of the complexity of the sinonasal anatomy with the finding of mainly advanced tumours, the presented individual silicone brachytherapy applicator has proven to be useful and meaningful for endocavitary brachytherapy of malignancies of the nasal cavities, paranasal sinuses and nasopharynx.

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Section: Discussionmentioning

confidence: 99%

“…In our study, we preferred the use of individual radiation applicators in treating the sinonasal and nasopharyngeal malignancies due to their ability to adjust geometrically perfectly and to apply precisely irradiation [8], as well as to reduce the potential radiation side effects.…”

Section: Introductionmentioning

confidence: 99%

Customized individual applicators for endocavitary brachytherapy in patients with cancers of the nasal cavity, sinonasal region and nasopharynx

Kadah

Niewald

Papaspyrou

et al. 2015

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

Ein individueller Silikonstrahlenapplikator für die nasopharyngeale Brachytherapie

Abstract: The presented individual silicon applicator is suited for intracavitary brachytherapy of the nasopharynx being an valuable contribution in the primary treatment regime of nasopharyngeal cancer.

Cited by 1 publication

References 13 publications

Customized individual applicators for endocavitary brachytherapy in patients with cancers of the nasal cavity, sinonasal region and nasopharynx

Customized individual applicators for endocavitary brachytherapy in patients with cancers of the nasal cavity, sinonasal region and nasopharynx

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