1950
DOI: 10.1007/bf02154049
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Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter

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1952
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Cited by 111 publications
(17 citation statements)
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“…Especially, protoveratrines, which reduced peripheral resistance in the peripheral arterial beds by reflex inhibition of sympathetic vasoconstrictor tone (11), excerted hypotensive effect much more marked in the SH rats than in the N rats. Hydralazine, to which the SH rats were more sensitive than the N rats, has been reported to respond with adrenolytic action (12) and inhibit vasoconstriction induced by serotonin (13), in addition to its direct action on vascular smooth muscle. Therefore, the greater sensitivity of the SH rats to hydralazine may be reflected to a participation of vasoconstriction by endogenous catecholamines and serotonin to the hypertension, since Tabei (14) has shown, in his histochemical studies on the adrenal medulla, that the dimen sional ratio of noradrenaline storing cells was prominently increases in association with the development of hypertension.…”
Section: Discussionmentioning
confidence: 99%
“…Especially, protoveratrines, which reduced peripheral resistance in the peripheral arterial beds by reflex inhibition of sympathetic vasoconstrictor tone (11), excerted hypotensive effect much more marked in the SH rats than in the N rats. Hydralazine, to which the SH rats were more sensitive than the N rats, has been reported to respond with adrenolytic action (12) and inhibit vasoconstriction induced by serotonin (13), in addition to its direct action on vascular smooth muscle. Therefore, the greater sensitivity of the SH rats to hydralazine may be reflected to a participation of vasoconstriction by endogenous catecholamines and serotonin to the hypertension, since Tabei (14) has shown, in his histochemical studies on the adrenal medulla, that the dimen sional ratio of noradrenaline storing cells was prominently increases in association with the development of hypertension.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, a central mechanism of action, in addition to the peripheral vasodilating effect, is a possible explanation, as already suggested by earlier experimental works. 31 " 33 Indeed, the increase in HR after cadralazine treatment could be due to sympathetic stimulation or to parasympathetic withdrawal, or to both, based on a neurogenic imbalance of central origin. Finally, the significant relationship between the change in HR and change in CCA tangential tension suggests, in both normal and hypertensive subjects, that the level of tangential tension, although not the only cause of the reflex tachycardia, may still influence the HR response.…”
mentioning
confidence: 99%
“…l-Hydrazinophthalazine (Ciba BA-5968 or Apresoline) is the basic chemical compound and one of several substituted compounds which have in common the properties of (a) increasing renal blood flow and (b) reducing arterial pressure in both animals and man (12)(13)(14)(15)(16).…”
mentioning
confidence: 99%
“…It has been shown that this drug antagonizes the pressor action of epinephrine and to a lesser extent that of nor-epinephrine (14,(17)(18)(19)(20). It abolishes the pressor effect brought about by centripetal vagus stimulation and thought due to serotonin (21), and it has an inhibitory effect against the National Heart Institute, U the pressor action of angiotonin and possibly other factors causally related to hypertension (22)(23)(24).…”
mentioning
confidence: 99%