Eine neue synthese von vinblastin-derivaten III

Schill, Gotteried; Priester, C. U.; Windhövel, Udo Frank; Fritz, Hans

doi:10.1016/s0040-4020(01)86862-9

Cited by 17 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…334–339 The condensation between the amine and pentafluorophenyl esters was applied to the successful synthesis of three different ring systems of bridged lactams. 336–338 The presence of an additional substituent (cf. 195b ) 336 was found to be crucial in obtaining bridged products.…”

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

“…336–338 The presence of an additional substituent (cf. 195b ) 336 was found to be crucial in obtaining bridged products. In contrast, the cyclization of the indole-derived amino acids was less general, affording only a [4.4.1] ring system in modest yield (Scheme 50).…”

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

“…However, in contrast to the transannular amidation reactions, 336–343 these approaches are limited to specific examples. Arata reported the Dieckmann condensation of amido ester 209 to give the corresponding bridged lactam in 30% yield (Scheme 54a).…”

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

“…337 Although these authors also accomplished a related α-arylation of [4.4.1] ring system, 339 the reaction of a bridged lactam with [4.3.1] scaffold was unsuccessful due to its instability to the reaction conditions. 336 …”

Section: Reactivity Of Bridged Lactams and Related Heterocyclesmentioning

confidence: 99%

See 3 more Smart Citations

Chemistry of Bridged Lactams and Related Heterocycles

2013

View full text Add to dashboard Cite

CONTENTS 1. Introduction 5702 2. General Properties of Bridged Lactams 5703 2.1. Distortion Parameters of Bridged Lactams 5703 2.2. Bond Lengths of Bridged Lactams 5703 2.3. Spectroscopic Properties of Bridged Lactams 5703 2.4. Analogy of Bridged Lactams to Bridgehead Olefins 5704 2.5. Chemical and Biological Significance of Distorted Amides 5704 3. Synthesis of Historically Important Bridged Lactams 5704 3.1. Quinuclidone Derivatives 5704 3.2. Adamantanone Derivatives 5707 4. Synthesis of Bridged Lactams with the N−(CO) Bond on a Two-Carbon or Larger Bridge, ([m. (≥2).n] Type) 5708 4.1. Condensation Reactions Forming the N− C(O) Bond 5708 4.2. Heck Reactions 5711 4.3. Diels−Alder Reactions 5712 4.4. Carbene Insertion Reactions 5713 4.5. Reactions via Radical Intermediates 5714 4.6. Miscellaneous Examples 5714 5. Synthesis of Bridged Lactams with the N−(CO) Bond on a One-Carbon Bridge, ([m.1.n] Type) 5715 5.1. Carbene Insertion Reactions 5715 5.2. Schmidt Reactions 5716 5.3.

show abstract

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

Section: Synthesis Of Bridged Lactams With N–(co) Bond On One-carbmentioning

confidence: 99%

Section: Reactivity Of Bridged Lactams and Related Heterocyclesmentioning

confidence: 99%

See 2 more Smart Citations

Chemistry of Bridged Lactams and Related Heterocycles

2013

View full text Add to dashboard Cite

show abstract

“…Another model study, using harmicine as the starting point, was published in 1987 by Schill and coworkers [41][42][43]. The study was aimed at the synthesis of vinblastine beginning with one-half of this bisindole alkaloid molecule.…”

Section: Methodsmentioning

confidence: 99%