“…For this reason, Richert oxidized thioethers immediately after every coupling step with Oxone [30]. Bl‰ttler and Kˆnig also chose this strategy for the synthesis of their dSNAs and rSNAs, respectively [32] [33]. One way to manage solubility in longer oligonucleotide analogs is to introduce an anionic group at the end of the oligomer.…”
“…For this reason, Richert oxidized thioethers immediately after every coupling step with Oxone [30]. Bl‰ttler and Kˆnig also chose this strategy for the synthesis of their dSNAs and rSNAs, respectively [32] [33]. One way to manage solubility in longer oligonucleotide analogs is to introduce an anionic group at the end of the oligomer.…”
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