Einflu� totaler Nahrungskarenz auf Serumproteinkonzentrationen

Fateh‐Moghadam, A.; Schwandt, P.; Sandel, P.; Vogt, William H.; Kling, S.

doi:10.1007/bf01489347

Cited by 14 publications

(4 citation statements)

References 11 publications

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“…Immune dysfunction has been observed in chronically undernourished subjects [47]. Starvation itself for 5-10 days does not affect immunoglobulin levels [48][49][50] and an increase has been observed in obese subjects during fasting [51]. However, it remains to be shown whether reduced immunoglobulins (Table 4) is due to a synergistic effect of exercise and starvation.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

Bøyum

Wiik

Gustavsson³

et al. 1996

Scand J Immunol

134

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Moderate exercise appears to stimulate the immune system, but there is good evidence that intense exercise can cause immune deficiency. In the present study the authors examined the effect of continuous physical exercise (35% of VO2 max), calorie deficiency and sleep deprivation on the immune system of young men participating in a 5–7 days military training course. There was a two–three fold increase of neutrophils from day 1, the values remained high and decreased slightly at the end of the course. Monocyte counts also increased with a pattern similar to that of neutrophils. Eosinophils decreased to 30% of control and lymphocyte numbers decreased by 30–40%. All the major subgroups (CD4 T cells , CD8 T cells, B cells, NK cells) were reduced. Neutrophil function, as tested by measuring chemotaxis, was significantly stimulated during the first days of the course, in particular in the group with the lowest calorie intake. The mitogenic response of lymphocytes to PHA and Con A was variable, ranging from stimulation during one course to no effect in another course. Serum levels of immunoglobulins decreased significantly during the course. IgG was reduced by 6–7%, IgA by 10–20% and IgM by 20–35%. The authors found no changes of interleukin 1, 2 and 4 during the course, but a (12–20%) reduction (P<0.01) of interleukin 6 , and an increase (P<0.01) of granulocyte–macrophage colony stimulating factor. Altogether the results from the ranger course present a mixed‐up picture. The non‐specific phagocyte‐related immunity was enhanced. On the other hand, the data indicate that even a moderate physical activity, around the clock, caused significant suppression of a number of parameters reflecting the status of the specific, lymphocyte‐related immunity. It is noteworthy, however, that there was no significantly increased infection rate during the course or in the first 4–5 weeks thereafter.

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Section: Discussionmentioning

confidence: 99%

The Effect of Strenuous Exercise, Calorie Deficiency and Sleep Deprivation on White Blood Cells, Plasma Immunoglobulins and Cytokines

Bøyum

Wiik

Gustavsson³

et al. 1996

Scand J Immunol

134

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“…The decrease in potassium is a well-known phenomenon (23). The plasma proteins prealbumin, retinol-binding protein, and haptoglobin decreased, as has been reported by others (24). The levels of retinol-binding protein have been suggested to be good indicators of vitamin A concentrations (25); however, the patients reported no symptoms attributable to vitamin A deficiency.…”

Section: Effects Of Fasting (Period 2 Versus Period 3)mentioning

confidence: 57%

Vegetarian Fasting of Obese Patients: A Clinical and Biochemical Evaluation

Sörbris¹,

Aly²,

Nilsson‐Ehle³

et al. 1982

Scandinavian Journal of Gastroenterology

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The effects of vegetarian fasting were evaluated in 14 grossly obese patients who participated in a program comprising 5 weeks' fasting in a lactovegetarian health center. Before and after the fasting period the patients were hospitalized and put on a standardized weight-maintaining diet; at the health center they consumed vegetable juices containing less than 1 MJ and 3 g of protein per day. The weight reduction (mean +/- S.D.) was 13.4 +/- 5.0 kg (from 132.0 +/- 27.2 to 118.6 +/- 16.1 kg). Except for the first few days the patients had no severe hunger sensations. No severe adverse clinical effects were noted. The laboratory status--comprising serum or plasma levels of minerals, protein, and lipids; hematological data; and variables reflecting liver and thyroid function--revealed abnormal group mean values only for ferritin and the acute-phase reactants haptoglobin, C-reactive protein, and anti-chymotrypsin in the obese. The levels of potassium, retinol-binding protein, and haptoglobin decreased, and aminotransferase and lactate dehydrogenase activities and free fatty acid and glycerol concentrations increased as a result of the fasting. The most striking effect of the weight reduction was an increase in the HDL cholesterol levels. Fasting according to the described regimen thus seems to provide a safe method for treatment of obese patients.

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“…In fact, the plasma concentrations of total protein, albumin, and retinol-binding protein remain unchanged during a VLED weight-loss program [6]. By contrast, total starvation for 3 weeks decreases the levels of haptoglobin, transferrin, retinol-binding protein, and immunoglobulins [19,59], but do not affect mean plasma albumin levels [19,35,59].…”

Section: Are Vleds Adequate?mentioning

confidence: 93%