Einfluß der glomerulären Filtrationsrate auf die tubuläre Glucosereabsorption bei Kindern

Maximal Tubular Reabsorption of Glucose in Infants and Children

“…In the present study a positive correlation was found between TmG and CIrl in different infants and children. This is in agreement with early findings of Smith et al (38) in adults, later reaffirmed by Vitelli et al (47), and by Gekle et al (15) in infants. It also was shown by physiologists in dogs (7,18,20,27) and in rats (46 A positive correlation between TmG/CI1, and plasma glucose concentration was demonstrable only in infants, but not in children.…”

“…Infants usually are considered to have lower rates of Tmo and Tm,/CIll, indicating tubular immaturity and glomerular preponderance in this respect. There are, however, only two reports (15,43) available to support this view. In the report by Tudvad no exact figures are given, neither for Tm, nor GFR, and furthermore, ''no actual attempts were made at determining the glucose Tm" in that study.…”

“…Its capacity is generally considered to be rate limited, as originally described by Shannon & Fisher (35) in dogs, and the maximal rate was termed tubular maximum for glucose (TmG) by Smith et al (38). In recent years, however, much evidence has accumulated, that a fixed tubular maximum does not indeed exist for glucose, but that reabsorption depends on many factors, including GFR (15,20,46), intratubular flow rate (6, 22,23), fluid reabsorption (6, 41), and extracellular fluid volume (29).…”

“…There are relatively few data in the literature on normal values of TmG in infants and children (15,17,39,43,44). In our laboratory glucose loading was performed in infants and children for various diagnostical reasons in order to determine the TmG.…”