Einfluß von Alter und Geschlecht auf die Entwicklung und Differenzierung der Aktivitätsmuster von Enzymen des Steroidhormon-Stoffwechsels in der Leber von Ratten zweier verschiedener Tierstämme

Schriefers, Herbert; Ghraf, Rüdiger; Hoff, Hanns-Georg; Ockenfels, H.

doi:10.1515/bchm2.1971.352.2.1363

Cited by 24 publications

(8 citation statements)

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“…Men and women between the ages of 22 and 36 years contain significantly more cortisol in subcutaneous connective tissue than those aged 37-51 years (Shou et al 1967). The enzymes metabolizing corticosteroid s also increase in activity in liver with advancing age (Kuntzman, Welch & Conney, 1966;Schriefers, Ghraf, Hoff & Ockenfels, 1971). …”

Section: Resultsmentioning

confidence: 99%

Influence of Sex and Age on the Cortisol Content of Peripheral Tissues and Adrenal Glands in the Guinea-Pig

Fazekas¹,

Homoki²,

Teller³

1974

Journal of Endocrinology

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SUMMARY The influence of age and sex on the cortisol content of adrenals, liver, kidney, lung, heart, spleen, muscle, cerebrum, brain stem and blood was studied in white guinea-pigs. In prepuberal animals no significant difference between sexes was found in the cortisol content of different tissues. In adult female animals, the blood cortisol level was significantly higher than in the male animals. Significantly more cortisol was found in kidneys of adult male than of female animals. In adult guinea-pigs, the cortisol content was lower in every tissue examined, except liver, compared with young animals. These differences were highly significant. In female guinea-pigs the decrease in tissue cortisol content with age was more pronounced than in male animals.

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Section: Resultsmentioning

confidence: 99%

Influence of Sex and Age on the Cortisol Content of Peripheral Tissues and Adrenal Glands in the Guinea-Pig

Fazekas¹,

Homoki²,

Teller³

1974

Journal of Endocrinology

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“…The determination of cytoplasmic 17/î-hydroxysteroid dehydrogenase ), microsomal /l4-5a-hydrogenase (Schriefers et al 1971) and microsomal 3a-hydroxysteroid dehydrogenase (Hoff Se Schriefers 1973) activity is described elsewhere.…”

Section: Determination Of Enzyme Activitiesmentioning

confidence: 99%

Regulation of the Activities of the Enzymes Involved in the Metabolism of Steroid Hormones in Rat Liver: The Effect of Administration of Anterior Hypophyseal Hormones and Gonadotrophin Preparations to Hypophysectomized Rats

Lax¹,

Ghraf²,

Schriefers³

et al. 1976

Acta Endocrinologica

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A crude human hypophyseal extract (HE), as well as human growth hormone (GH), ovine prolactin (PRL) and commercial preparations of ACTH, TSH, pregnant mare's serum gonadotrophins (PMS) and chorionic gonadotrophin (CG) were tested for their ability to induce the activities of cytoplasmic 17\g=b\-hydroxysteroiddehydrogenase and microsomal \g=D\4-5\g=a\-hydrogenase and to repress the activities of microsomal 3\ g=a\ \ x=r eq-\ and 3\g=b\-hydroxysteroid dehydrogenases in the liver of hypophysectomized rats. The activity of 17\g=b\-hydroxysteroid dehydrogenase was not affected by any of the administered hormones. For the other enzymes, only PRL was effective in causing changes in the activities; the repressive effect on 3\g=a\-hydroxysteroid dehydrogenase activity was highly significant (P < 0.001) These results indicate that PRL is involved in the regulation of at least some of the enzyme activities of hepatic steroid hormone metabolism.

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“…The livers were excised and homogenized (3 g liver to 12 ml 0.25M sucrose). Cell fractions were prepared as previously described [10] .…”

Section: Treatment Of Animalsmentioning

confidence: 99%

“…The activities of cortisone oc-reductase (substrate testosterone), total steroid hydroxylases (substrate testosterone; reaction products total CigOasteroids) and 20-hydroxysteroid dehydrogenase (substrate cortisone) were tested in the prescence of a NADPH-generating system as previously described [10] . 3 -and 3ß-hydroxysteroid dehydrogenase activity (substrate 5a-dihydrotestosterone; coenzyme NADH) were determined according to Hoff and SchriefersV*^, A 4 -3ß-hydroxysteroid dehydrogenase activity (substrate 4-androstene-3ß,17ß-diol; coenzyme NADP®) according to Lax and SchrieferslW, and 17ß-hydroxysteroid dehydrogenase activity (substrate oestradiol; coenzyme NAD®) according to Ghrafet alW.…”

Section: Determination Of Enzyme Activitiesmentioning

confidence: 99%

The Role of the Hypophysis in the Regulation of Sex Differences in the Activities of Enzymes involved in Hepatic Steroid Hormone Metabolism

Lax¹,

Hoff²,

Ghraf³

et al. 1974

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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It is generally accepted that the mainte-In both sexes 17ß-hydroxysteroid dehydrogenase nance of sex differences in the activities of enzymes and total steroid hydroxylases exhibit activities involved in hepatic steroid hormone metabolism is typical for the normal female. In both sexes 20-the result of the modifying action of androgens on hydroxysteroid dehydrogenase and 16a-hydroa basic female activity pattern inherent to both xylase activities lie between the normal male and sexes. In this respect the enzyme activities behave female values. in the same manner as a typical peripheral sex In both sexes A 4 -3ß-hydroxysteroid dehydrogenase organ. and 3ß-hydroxysteroid dehydrogenase exhibit acHowever, for the hepatic enzyme activities, the tivities typical for the normal male. consequences of hypophysectomy do not corre-In both sexes 3a-hydroxysteroid dehydrogenase spond to those of gonadectomy as is the case for and cortisone -reductase have developed actithe peripheral sex organs. In contrast to the vities which lie beyond the normal male values, peripheral sex organs, the responsiveness of the outside the range of activities encountered in enzyme activities to exogenous testosterone is lost, animals with intact pituitaries. In the case of 3 -Moreover, the pattern of enzyme activities ob-hydroxysteroid dehydrogenase, this represents an served after hypophysectomy differs substantially abnormal induction, in the case of cortisone afrom that found after gonadectomy.reductase, an abnormal repression.

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Einfluß von Alter und Geschlecht auf die Entwicklung und Differenzierung der Aktivitätsmuster von Enzymen des Steroidhormon-Stoffwechsels in der Leber von Ratten zweier verschiedener Tierstämme

Cited by 24 publications

References 0 publications

Influence of Sex and Age on the Cortisol Content of Peripheral Tissues and Adrenal Glands in the Guinea-Pig

Influence of Sex and Age on the Cortisol Content of Peripheral Tissues and Adrenal Glands in the Guinea-Pig

Regulation of the Activities of the Enzymes Involved in the Metabolism of Steroid Hormones in Rat Liver: The Effect of Administration of Anterior Hypophyseal Hormones and Gonadotrophin Preparations to Hypophysectomized Rats

The Role of the Hypophysis in the Regulation of Sex Differences in the Activities of Enzymes involved in Hepatic Steroid Hormone Metabolism

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