Einfluss von Lebensbedingungen und Verhaltensweisen auf die Entwicklung von Immunsystem und Allergien im Ost-West-Vergleich (LISA)

Brockow, Inken; Zutavern, Anne; Franke, Kurt; Schaaf, Beate; Berg, Andrea von; Krämer, Ursula; Lehmann, Irina; Herbarth, Olf; Borte, Michael; Bauer, Carl Peter; Wichmann, Heinz‐Erich; Heinrich, Joachim

doi:10.1007/s00112-007-1527-4

Cited by 6 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus we lately demonstrated for children from the urban portion of the GINIplus and LISAplus birth cohorts [25,26] (Munich, South Germany), that asthma, hay fever, eczema and allergic sensitization against outdoor allergens were associated with TAP. [24] It is unknown, whether effects also emerge in rural, small town areas, where pollution is lower.…”

Section: Introductionmentioning

confidence: 98%

Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas

Krämer¹,

Sugiri²,

Ranft³

et al. 2009

Journal of Dermatological Science

107

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 98%

Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas

Krämer¹,

Sugiri²,

Ranft³

et al. 2009

Journal of Dermatological Science

107

View full text Add to dashboard Cite

“…We used data from the birth cohort “ Influence of Life-style factors on Development of the Immune System and Allergies in East and West Germany (LISA),” which was described in detail elsewhere (18, 19); 3,094 healthy term newborns from four regions of Germany (Munich, Wesel, Leipzig, and Bad Honnef) were recruited between December 1997 and January 1999. Of these, 2,664 (86.1%) were followed up until the age of 2 years (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA

et al. 2019

View full text Add to dashboard Cite

The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers ( p < 0.05), while 11 (95%-CI: 6, 17) spurious associations were expected due to multiple testing. In exploratory multivariable analyses, we observed associations between seven investigated IgG titers and 10 exposures; either administered vaccines [e.g., higher anti-hRSV IgG titer in BCG-vaccinated children (regression-coefficient in standard-deviation-units: 0.38; 95%-CI: 0.12, 0.65)] or infections [e.g., higher anti-measles IgG titer in children with reported chickenpox (0.44; 95%-CI: 0.08, 0.80)]. Our results indicate the existence of associations between immunogenic exposures and unrelated antibody titers. Further studies investigating the underlying immunological mechanisms are required.

show abstract

“…On the other hand, infant feeding is also important to develop GM because mother milk is not sterile and is the first bacteria to colonize the gut [69]. Breast milk is a source of probiotics and other bacteria [71] containing more than 700 species [70]. The median bacterial load is 10 6 bacterial cells/Ml [71].…”

Section: Gut Microbiota and Diabetes Typementioning

confidence: 99%

“…Breast milk is a source of probiotics and other bacteria [71] containing more than 700 species [70]. The median bacterial load is 10 6 bacterial cells/Ml [71]. Streptococci and Staphylococci are predominant bacterial genera in human milk [69].…”

Section: Gut Microbiota and Diabetes Typementioning

confidence: 99%

“…Weissella, Leuconostoc, Staphylococcus, Streptococcus, and Lactococcus are predominant in colostrum and are thought to modify the lactation to increase Veillonella, Leptotrichia, and Prevotella for over 6 months [71]. In this line, milk from obese mothers contains less-diverse bacteria than normal-weight mothers and has pro-inflammatory properties [72,73,74].…”

Section: Gut Microbiota and Diabetes Typementioning

confidence: 99%

See 1 more Smart Citation

The Microbiome and the Epigenetics of Diabetes Mellitus

Angarita¹,

Pirela²,

Díaz³

et al. 2018

Diabetes Food Plan

View full text Add to dashboard Cite

Gut microbiota (GM) in the epigenetic mechanisms of diabetes mellitus and the reprogramming of the cells is a novel and emerging concept. The purpose of this chapter is to describe the modification of the GM and its relation with DM2. The increased risk of this disease is associated with changes in the amount of Bacteroides/Clostridium in the Firmicutes/Bacteroidetes ratio of people having DM. A dysbiosis state associated generates low-grade inflammation with similar characteristics that occur under metabolic syndrome, whose pattern is recognized by Toll-like receptor that recognizes important patterns of immunity. The synthesis of butyrate generated by intestinal microorganisms inhibits the metabolic pathway of histone deacetylase, promoting cellular differentiation, proliferation, and insulin resistance. On the other hand, the direct relationship between the neuroendocrine system and the GM has been demonstrated through the production of serotonin by enterochromaffin cells, whose action could influence the etiopathogenic factors of DM2.

show abstract

Einfluss von Lebensbedingungen und Verhaltensweisen auf die Entwicklung von Immunsystem und Allergien im Ost-West-Vergleich (LISA)

Cited by 6 publications

References 26 publications

Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas

Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas

Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA

The Microbiome and the Epigenetics of Diabetes Mellitus

Contact Info

Product

Resources

About