Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus

Fathoni, Zuhrotun Ulya; Indra, Rasjad; Supranowo, Supranowo

doi:10.21776/ub.jkb.2014.028.01.2

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Ox-LDL upregulates Protein Arginine Methyltransferases (PRMTs), enzyme catalyzer arginine methylation to form ADMA Anthocyanin as (24). polyphenol antioxidant in EVOO has double bonds and hydroxyl groups that bind free radicals and inhibit LDL oxidation at the initiation and propagation stage, so radical compounds do not have enough energy to react with other lipid molecules (25).…”

Section: Increase Systolic and Diastolic Pressure As Marker Of Preeclmentioning

confidence: 99%

The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model

Silvani

Maharani

Lovita

2020

JKB

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<p>Preeclampsia, as one of the most common pregnancy-specific diseases, causes high maternal-fetal morbidity and mortality in almost every country. Placental vascular abnormalities in preeclamptic women can cause chronic hypoxia and impaired fetal nutrition, so fetal growth retardation often occurs. EVOO has strong antioxidant effect is assumed to prevent nutritional disorders in the fetus. This study aimed to determine the effect of EVOO on fetal birth weight in a preeclampsia rat model. This research was laboratory research conducted in vivo with a Post Test Only Control Group design which consisted of five groups; negative control group, positive control group (pre-eclampsia rat model), dose 1, 2, and 3 groups that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure and proteinuria measurements were carried out at the 12, 15 and 19 day of pregnancy. After sacrificed, fetal weight was measured immediately using analytical balance. The result of this study showed that there was a significant reduction of fetal weight between negative control and positive control group (p=0.020), meanwhile no significant differences among positive control, dose 1 and dose 2 group (p=0.90 and p=0.142) but statistically significant to dose 3 group (p=0.005). EVOO administration increases fetal weight in doses group by its AA and DHA in Long-Chain Poly Unsaturated Fatty Acids (LCPUFA) within. The optimal dose of EVOO to increase fetal weight is 2 mL/day.</p>

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Section: Increase Systolic and Diastolic Pressure As Marker Of Preeclmentioning

confidence: 99%

The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model

Silvani

Maharani

Lovita

2020

JKB

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“…The Effect of Rosella Flower on Rats Given Baked-Food Diet (Falyani et al) tioxidant, hepato and nefro-protective, antiinflammatory, and anti-cholesterol [7,8].…”

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confidence: 99%

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Falyani

Soeharto

Widjajanto

et al. 2016

JELS

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Advanced Glycation Endproducts (AGEs) or so-called glycotoxin can be triggered by heated food in which the Maillard reaction occurs. One type of glycotoxins is CML. Accumulated N-Carboxymethyl-Lysine (CML) can cause inflammation of organs, e.g. liver. Rosella flowers contain anthocyanin compound that has anti-glycation and antioxidant effects. This study aimed to determine the effect of ethanol extract of Rosella on CML serum level, IL-6 level, and NF-ƙB activation in the liver of mice fed with baked food. This study used post-test design using 25 Wistar rats aged 3-4 months old that were divided into 5 groups, namely negative control group, positive control group, treatment groups given Rosella extract dose of 200mg.kgBW . Baked feed was given for 12 weeks, and Rosella ethanol extract was administered in the 9 th to 12 th week. The examination on CML serum and IL-6 of the liver was using ELISA method. Immunofluorescent staining was used to determine NF-ƙB activation in the liver using a confocal microscope. CML serum is proven to increase significantly (p = 0.000). The effective dose of Rosella flower extract to prevent CML Serum increase is 200 mg.kgBW, whereas a dose of 400 mg.kgBW -1 can decrease IL-6 level and NF-ƙB activation. Ethanol extract of Rosella flower decrease the levels of N-carboxymethyl-lysine serum, IL-6, and NF-ƙB activation in the liver of rats given baked-food diet.

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Comparison of the effectiveness of avocado seeds (Persea americana mill.) and roselle flowers (Hibiscus sabdariffa l.) As hypolipidemic ingredients in terms of liver histopathology and weight of hypercholesterolemia mice

Putri

Fachrezi

Kusmahardhika

et al. 2023

The 4TH INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICoLiST)

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Ekstrak Rosela Menurunkan Perlemakan dan Ekspresi ADMA Hepar akibat Diet Aterogenik pada Tikus

Cited by 3 publications

References 1 publication

The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model

The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Comparison of the effectiveness of avocado seeds (Persea americana mill.) and roselle flowers (Hibiscus sabdariffa l.) As hypolipidemic ingredients in terms of liver histopathology and weight of hypercholesterolemia mice

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