<p>Preeclampsia, as one of the most common pregnancy-specific diseases, causes high maternal-fetal morbidity and mortality in almost every country. Placental vascular abnormalities in preeclamptic women can cause chronic hypoxia and impaired fetal nutrition, so fetal growth retardation often occurs. EVOO has strong antioxidant effect is assumed to prevent nutritional disorders in the fetus. This study aimed to determine the effect of EVOO on fetal birth weight in a preeclampsia rat model. This research was laboratory research conducted in vivo with a Post Test Only Control Group design which consisted of five groups; negative control group, positive control group (pre-eclampsia rat model), dose 1, 2, and 3 groups that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure and proteinuria measurements were carried out at the 12, 15 and 19 day of pregnancy. After sacrificed, fetal weight was measured immediately using analytical balance. The result of this study showed that there was a significant reduction of fetal weight between negative control and positive control group (p=0.020), meanwhile no significant differences among positive control, dose 1 and dose 2 group (p=0.90 and p=0.142) but statistically significant to dose 3 group (p=0.005). EVOO administration increases fetal weight in doses group by its AA and DHA in Long-Chain Poly Unsaturated Fatty Acids (LCPUFA) within. The optimal dose of EVOO to increase fetal weight is 2 mL/day.</p>

Objective: This study aimed to determine the effect of Extra Virgin Olive Oil (EVOO) on vasodilator enzyme by repairing angiogenic function in rat model of preeclampsia. Materials and methods: This research consisted of five groups; negative control (normal pregnant rats) group, positive control (preeclampsia rat model) group, preeclampsia rat model groups given EVOO in 3 different doses (0.5 ml/day, 1 ml/day, and 2 ml/day, respectively). Blood pressure measurements were carried out on day 12, 15, and 19 of pregnancy. After the rats were sacrificed, the placentas were collected to determine endothelial Nitric Oxide Synthase (eNOS) level of maternal plasma to determine soluble Fms-like Tyrosine Kinase 1 (sFlt-1) and Vascular Endothelial Growth Factor (VEGF) level. Results: There were significant higher sFlt-1 level (p < 0.001), lower VEGF level (p = 0.009), and lower eNOS level (p = 0.034) between negative and positive control groups. After EVOO administration, sFlt-1 level was lower in dose 1 and 2 groups but higher in dose 3 group in accordance with VEGF and eNOS levels that were increasing both in dose 1 and dose 2 groups but decreasing in dose 3. There were significant differences between positive control and dose 1 (p = 0.015) and dose 2 (p = 0.001) in sFlt-1 level. None of all dose groups were statistically different with positive control group in VEGF level (dose 1 p = 0.601; dose 2 p = 0.297; dose 3 p = 0.805). eNOS levels of all dose groups were statistically different from that of the positive control group (dose 1 p = 0.014; dose 2 p = 0.001; dose 3 p = 0.024). Conclusion: Administration of EVOO modulates eNOS as vasodilator enzyme by repairing the angiogenic function indicated by decreased sFlt-1 level and increased VEGF in rat model of preeclampsia.

Increased levels of violence and sexual abuse of children in Malang Regency, and the process of development of the child, where at the age of 9-12 years old children begin pubert, the elementary school child needs to get sexuality education. Sexuality education would be better if given according to the needs of children. The purpose of this study is to analyze the needs for sexuality education at primary school children in Gondanglegi Sub-District. This study used quantitative method, explanatory research with cross sectional approach. Data collection using questionnaires on 317 samples at 24 elementary schools. Data analysis using univariate, with chi-square bivariate and multivariate logistic regression. Results showed that the majority of respondents (70.03%) require sexuality education with avariables effect on sexuality education needs is information (OR =4,870), knowledge (OR =3,028), and attitudes toward sexuality education (OR =4,271). ABSTRAKSemakin tingginya kekerasan dan pelecehan seksual pada anak di wilayah Kabupaten Malang serta adanya proses tumbuh kembang anak, dimana pada usia 9-12 tahun anak mulai memasuki masa pubertas, maka anak sekolah dasar perlu mendapatkan pendidikan seksualitas. Dan pendidikan seksualitas akan lebih baik jika diberikan sesuai kebutuhan anak.Tujuan dari penelitian ini adalah menganalisis kebutuhan pendidikan seksualitas pada anak sekolah dasar di Kecamatan Gondanglegi Kabupaten Malang.Metode penelitian yang digunakan adalah metode kuantitatif dengan rancangan explanatory research dengan pendekatan cross sectional. Pengumpulan data menggunakan kuesioner pada 317 sampel pada 24 sekolah dasar. Analisa data secara univariat, bivariat dengan chi-square dan multivariate dengan regresi logistik.Hasil penelitian menunjukkan bahwa sebagian besar responden (70.03%) membutuhkan pendidikan seksualitas dengan variabel yang berpengaruh pada kebutuhan pendidikan seksualitas adalah informasi (OR= 4.870), pengetahuan (OR=3.028), dan sikap terhadap pendidikan seksualitas (OR= 4.271).

High-risk pregnancy is a pregnancy that is likely to cause harm or complications to the mother and fetus. Given the high rate of disease transmission, the use of telehealth technology can be an effective and efficient way to deal with the spread of the virus. Telehealth is one solution to overcome the problem of access to health, with telehealth it can perform screening to detect high-risk pregnancies early, so that pregnant women can get continuous monitoring. Telehealth can operate as a filter that is able to expand and facilitate access to services, especially in the examination and screening of risks in pregnancy and can apply high risk detection instruments in pregnancy in applications, so as to facilitate decision making. Telehealth can detect high-risk pregnancies early, so that pregnant women can get continuous monitoring. The purpose of this activity is to conduct and determine the effectiveness of telehealth-based high-risk detection in pregnant women. The method of activity is in the form of community service through webinars and screenings which are carried out within 6 months online. The result of the activity is an increase in the knowledge of webinar respondents with an average pre-test value of 120 and post-test 157 out of a total of 200. Based on the results of screening using the SIBIDAN application, from 25 pregnant women in trimesters 1,2, and 3 who became respondents, the results were 52%, low risk group, 32% high risk group, and 16% very high-risk group. Therefore, further assistance, monitoring, and referral are needed to minimize pregnancy complications.

Development is an ongoing process and related to functional matters. One of the factors influencing development is the environment. Excessive and uncontrolled use of gadgets can adversely affect children's motor development, social abilities and communication. This study aims to analyze the relationship between the intensity of gadget use to social personal development, fine motor, gross motor and language in preschool age children (3-6 years). The study subjects were 135 children aged 36 to 72 months. Sampling is done by Purposive Sampling technique. Data retrieval using Denver II Sheet (which has been adapted for use in Indonesia) for early detection examination of child developmental disorders. The results of the study obtained the type of gadgets used by children: 82.5% smartphones, 4.4% tablets, 5.2% smartphones and tablets, 5.2% smartphones and laptops. Based on the type of application used: 8.1% learn (reading, writing, etc.), 35.6% video, 45.9% games and 10.9% puzzles. Meanwhile the intensity of gadget use in preschoolers was obtained 27.4% low intensity, 32.6% medium intensity and 40.0% children using gadgets with high intensity. Chi-square test results showed social personal development p 0.000; fine motor p 0.001; gross motor p 0.069 and language p 0.000.The conclusion of this study is the intensity of gadget use related to the development of social personal, fine motor and language in preschool children (36-72 months).