El eje microbiota-intestino-cerebro y sus grandes proyecciones

Gómez-Eguílaz, M.; Ramon-Trapero, J L; Pérez‐Martínez, Laura; Blanco, José Ramón

doi:10.33588/rn.6803.2018223

Cited by 28 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…hippocampal inflammation, and ultimately affect hippocampusdependent functions (Bostanciklioglu, 2019;Garcez et al, 2019;Gomez-Eguilaz et al, 2019). All these still require further experimental evidence, and we also lack human observational or interventional data to propose any clinical recommendations.…”

Section: Discussionmentioning

confidence: 99%

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Tang

Meng

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The study of the gut microbiota-brain axis has become an intriguing field, attracting attention from both gastroenterologists and neurobiologists. The hippocampus is the center of learning and memory, and plays a pivotal role in neurodegenerative diseases, such as Alzheimer’s disease (AD). Previous studies using diet administration, antibiotics, probiotics, prebiotics, germ-free mice, and fecal analysis of normal and specific pathogen-free animals have shown that the structure and function of the hippocampus are affected by the gut microbiota. Furthermore, hippocampal pathologies in AD are positively correlated with changes in specific microbiota. Genomic and neurochemical analyses revealed significant alterations in genes and amino acids in the hippocampus of AD subjects following a remarkable shift in the gut microbiota. In a recent study, when young animals were transplanted with fecal microbiota derived from AD patients, the recipients showed significant impairment of cognitive behaviors, AD pathologies, and changes in neuronal plasticity and cytokines. Other studies have demonstrated the side effects of antibiotic administration along with the beneficial effects of probiotics, prebiotics, and specific diets on the composition of the gut microbiota and hippocampal functions, but these have been mostly preliminary with unclear mechanisms. Since some specific gut bacteria are positively or negatively correlated to the structure and function of the hippocampus, it is expected that specific gut bacteria administration and other microbiota-based interventions could be potentially applied to prevent or treat hippocampus-based memory impairment and neuropsychiatric disorders such as AD.

show abstract

Section: Discussionmentioning

confidence: 99%

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Tang

Meng

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Related studies have shown that gut microbiota plays an important role in maintaining the homeostasis of T cells [18][19][20] . Recently, "intestine-brain axis" theory of the functional relationship between the intestine and the brain has become a new focus [21][22][23][24] . Benakis C et al 25) found that intestinal microbiota disturbance caused by ischemic stroke caused changes in T cell expression, and the induction of antibiotic therapy affected the inflammatory response and outcome of the stroke model.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

Zhang

Zhai

Qian

et al. 2020

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classic traditional Chinese medicine prescription for treating cerebral ischemia. The purpose of this study was to investigate the effect of TQHXD on intervening inflammatory response of ischemic stroke by regulating intestinal flora and repairing the intestinal barrier. A rat model of cerebral ischemia was established using middle cerebral artery occlusion (MCAO) and behavioral scores were performed. Additionally, the high throughput 16S rDNA sequence of intestinal bacteria in fecal samples of rat was also carried out. Our results showed that TQHXD could change the main components of intestinal flora in stroke rats, and reduced the excessive increase of Bacteroidetes, and also regulated the abnormal changes of abundance of some flora as well. In addition, the intestinal epithelial barrier was damaged after stroke, allowing bacterial metabolites to enter the blood, while TQHXD had an improved effect on this phenomenon. Meanwhile, pathological changes in the brain tissue and infarct volume was also alleviated by TQHXD. Due to the disorder of the intestinal flora and the destruction of the barrier, the peripheral immune imbalance caused an inflammatory reaction. TQHXD improved the imbalance of T cells, and inhibited the inflammatory response. Finally, the therapeutic transplantation of fecal microbiota also improved the outcome of stroke in rats. Our presented results suggest that TQHXD may improve the gut microbiota disorder and its induced inflammatory response after stroke, which could be a new target and mechanism for the treatment of stroke.

show abstract

“…There is bi-directional communication between gut microbes and vital human organs [13]. For instance, there is continuous bi-directional signaling between the brain and the gut through a system that is referred to as the gut-brain axis [156]. In addition, perturbations of the lung microbiota inside airways can also affect the composition of intestinal microbiota [157].…”

Section: Mitochondria and The Gut-brain Axis 81 Summary Of Key Physiological Functionsmentioning

confidence: 99%

COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota

Bókkon¹,

Kapócs

Vucskits³

et al. 2021

CMC

View full text Add to dashboard Cite

show abstract

El eje microbiota-intestino-cerebro y sus grandes proyecciones

Cited by 28 publications

References 0 publications

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats

COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota

Contact Info

Product

Resources

About