El humo del tabaco y su asociación con la caries dental en niños y niñas de 10 a 15 años atendidos en la unidad de odontología del departamento 9 de la Comunidad Valenciana

García, Smara Carbajosa; Llena, Carmen

doi:10.1590/s1135-57272011000200009

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Historically, the most common systemic diseases related to smoking are lung cancer and cardiovascular disease (Wellmann 1964). Although the relationship between caries and smoking has been documented (Carbajosa Garcia and Llena Puy 2011;Rooban et al 2011;Tomar and Winn 1999), very few studies have focused on understanding why smokers or children exposed to environmental tobacco smoke are prone to the development of caries. In the past, most tobacco research has focused on the relationship between smoking and periodontal disease, while more and more studies have established that smoking affects caries.…”

Section: Introductionmentioning

confidence: 99%

Effect of nicotine on cariogenic virulence of Streptococcus mutans

Huang

Zhou³

et al. 2016

Folia Microbiol

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Section: Introductionmentioning

confidence: 99%

Effect of nicotine on cariogenic virulence of Streptococcus mutans

Huang

Zhou³

et al. 2016

Folia Microbiol

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“…Historically, the most often mentioned systemic diseases related to smoking are lung cancer and cardiovascular diseases. 2 Although the relationship between caries and smoking has been documented, 3,4,5 very few studies have focused on the mechanisms why smokers or children exposed to environmental tobacco smoke are prone to caries development. Recently we reported that nicotine increases S. mutans biofilm formation and metabolic activity 6 as well as increased expression of antigen I/II, glucosyltransferases (GTF) and glucan-binding protein A (Gbp; manuscript in preparation).…”

Section: Introductionmentioning

confidence: 99%

Role of sortase in Streptococcus mutans under the effect of nicotine

Huang

Zhou

et al. 2013

Int J Oral Sci

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Streptococcus mutans is a common Gram-positive bacterium and plays a significant role in dental caries. Tobacco and/or nicotine have documented effects on S. mutans growth and colonization. Sortase A is used by many Gram-positive bacteria, including S. mutans, to facilitate the insertion of certain cell surface proteins, containing an LPXTGX motif such as antigen I/II. This study examined the effect of nicotine on the function of sortase A to control the physiology and growth of S. mutans using wild-type S. mutans NG8, and its isogenic sortase-defective and -complemented strains. Briefly, the strains were treated with increasing amounts of nicotine in planktonic growth, biofilm metabolism, and sucrose-induced and saliva-induced antigen I/II-dependent biofilm formation assays. The strains exhibited no significant differences with different concentrations of nicotine in planktonic growth assays. However, they had significantly increased (P≤0.05) biofilm metabolic activity (2- to 3-fold increase) as the concentration of nicotine increased. Furthermore, the sortase-defective strain was more sensitive metabolically to nicotine than the wild-type or sortase-complemented strains. All strains had significantly increased sucrose-induced biofilm formation (2- to 3-fold increase) as a result of increasing concentrations of nicotine. However, the sortase-defective strain was not able to make as much sucrose- and saliva-induced biofilm as the wild-type NG8 did with increasing nicotine concentrations. These results indicated that nicotine increased metabolic activity and sucrose-induced biofilm formation. The saliva-induced biofilm formation assay and qPCR data suggested that antigen I/II was upregulated with nicotine but biofilm was not able to be formed as much as wild-type NG8 without functional sortase A.

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Is secondhand smoke exposure associated with poor periodontal status in children and adolescents? A systematic review and meta-analysis

Oliveira

Ardenghi

et al. 2022

Eur Arch Paediatr Dent

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El humo del tabaco y su asociación con la caries dental en niños y niñas de 10 a 15 años atendidos en la unidad de odontología del departamento 9 de la Comunidad Valenciana

Cited by 5 publications

References 18 publications

Effect of nicotine on cariogenic virulence of Streptococcus mutans

Effect of nicotine on cariogenic virulence of Streptococcus mutans

Role of sortase in Streptococcus mutans under the effect of nicotine

Is secondhand smoke exposure associated with poor periodontal status in children and adolescents? A systematic review and meta-analysis

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