Abstract:Presentamos un breve resumen histórico y enfatizamos la importancia del uso del metformin, en el tratamiento de diabetes no insulino – dependiente basada en la experiencia europea y canadiense. Recomendamos la dosis de 500 mg debido a que se ha demostrado que la incidencia de acidosis láctica es pequeña, se consigue un buen cumplimiento de la dosis y puede ser combinado con otros antidiabéticos orales
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