The objective of this study was to establish a baseline for future studies that aim to determine possible contamination from human, agricultural and industrial activities. As well as the determination of the indices of environmental or geological contamination and enrichment factors of heavy metals Cr, Ni, Cu, Zn, As, Cd, Hg and Pb in agricultural soils of Constanza, Jarabacoa, Rancho Arriba and San José de Ocoa (SJO), municipalities located in the valleys of the Central mountain range of the Dominican Republic. The determination of the concentrations of heavy metals was carried out using the X-ray Fluorescence technique. Just like in Azua, San Juan de la Maguana (SJM) y Barahona in the southwest. Producer municipalities of vegetables, rice, beans, corn, melon, watermelon, tomato, banana, avocado, sugar cane and fodder for cattle. The concentration of 160 mg·kg −1 Probable Effect Level (PEL) of Cr according to the SQuiRTs table (USEPA-NOAA) for agricultural soils, were exceeded in 50% of the samples in SJM, SJO, Jarabacoa and Constanza; in Barahona and Azua by 20%. The PEL of 42.8 mg·kg −1 of the Ni was higher in more than 50% of the samples from SJM, Azua, Barahona and Jarabacoa; in SJO and Constanza at 35%. In the case of Cu with a PEL of 108 mg·kg −1 in SJO and Constanza, 5% of the samples exceeded its, in the other areas the concentrations were lower. Zn, As and Pb did not manage to exceed their respective PEL.