Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation

Kim, Min-Jong; Kim, Yeon-Yong; Choi, Young‐Ae; Baek, Moon‐Chang; Lee, Byungheon; Park, Pil-Hoon; Shin, Tae‐Yong; Kwon, Taeg Kyu; Khang, Dongwoo; Kim, Sang-Hyun

doi:10.3389/fphar.2018.00591

Cited by 29 publications

(34 citation statements)

References 57 publications

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“…Evidently, nothofagin, a dihydrochalcone of unprocessed rooibos tea, was reported to mitigate NF‐κB translocation, causing the diminution of TNF‐α and IL‐4 expression in antigen‐activated RBL‐2H3 cells (Kang et al, ). Moreover, elaeocarpusin from Elaeocarpus sylvestris significantly decreased TNF‐α and IL‐4 production via suppression of NF‐κB activation in mast cells (Kim et al, ). Besides, the suppressive effect of formononetin on NF‐κB activation also contributed to the attenuation of IL‐1β, IL‐6, and TNF‐α production (Xu & An, ).…”

Section: Resultsmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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Rhodomyrtus tomentosa was reported to contain various bioactive metabolites, especially phenolic compounds. In the present study, the suppressive activity of phenolic compound from R. tomentosa fruits on mast cell activation was investigated in vitro. The result showed that myricetin was isolated from R. tomentosa fruits and its characterization was identified by nuclear magnetic resonance spectroscopy. Notably, myricetin was found to be effective in inhibition of mast cell degranulation by attenuating the release of β‐hexosaminidase and the elevation of intracellular calcium. Moreover, myricetin exhibited inhibitory effect on the production of IL‐4 and Tumor necrosis factor alpha (TNF‐α) in a concentration‐dependent manner. Furthermore, high antioxidant activity of myricetin due to scavenging 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) and ABTS+ radicals was also evidenced. Notably, the activation of FcɛRI‐mediated signaling molecules including Syk, PLCγ, and NF‐κB was also suppressed by myricetin treatment. Accordingly, myricetin from R. tomentosa fruits could be suggested as a functional food for the amelioration of allergic diseases. Practical applications Polyphenol have been shown to exert various biological activities and health beneficial effects. Results from the present study revealed that myricetin from R. tomentosa fruits possesses the inhibitory effect on allergic response in mast cells. Therefore, myricetin from R. tomentosa fruits could be developed as a functional ingredient for the amelioration of allergic diseases.

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Section: Resultsmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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“…Passive cutaneous anaphylaxis (PCA) is widely used animal model to demonstrate the local anaphylaxis 28 . Anti-DNP IgE-sensitised mice were challenged intravenously with a mixture of 4% Evans blue and DNP-HSA.…”

Section: Resultsmentioning

confidence: 99%

Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells

Dhakal

Yang

Lee

et al. 2019

Sci Rep

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Mast cells play a crucial role in allergic diseases via the release of inflammatory mediators, particularly histamine and pro-inflammatory cytokines. Avenanthramide (Avn) C, a polyphenol found mainly in oats, is known to exhibit various biological properties. In this study, we aimed to evaluate the effectiveness of Avn C from germinated oats against mast cell-mediated allergic inflammation. For the in vitro study, RBL-2H3, mouse bone marrow-derived mast cells and rat peritoneal mast cells were used. Avn C (1–100 nM) inhibited the immunoglobulin (Ig)E-stimulated mast cells degranulation by suppressing phosphorylation of phosphoinositide 3-kinase and phospholipase Cγ1 and decreasing intracellular calcium levels. It inhibited IgE-stimulated secretion of inflammatory cytokines via suppression of FcεRI-mediated signaling proteins Lyn, Syk, Akt, and nuclear factor-κB. To verify the effects of Avn C in vivo , ovalbumin-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. Oral administration of Avn C dose-dependently attenuated the ASA reactions, as evidenced by the inhibition of hypothermia and reduction of elevated serum histamine, IgE, and interleukin-4 levels. Avn C also inhibited the PCA reactions, such as ear swelling and plasma extravasation. Our results suggested that Avn C from germinated oats might be a possible therapeutic candidate for mast cell-mediated allergic inflammation.

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“…This could be used to assess the anti-inflammatory activities of samples. Nuclear factor kappa B (NF-κB) is an important regulator of allergic inflammation, which controls the expression of pro-inflammatory mediators (Kim et al, 2018). When stimulated, NF-κB translocates to the nucleus, and regulates the expression of various transcription factors leading to the expression of pro-inflammatory enzymes like cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS), which are responsible for the stimulation of inflammatory signaling molecules (Ahmad et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Anti-allergic Inflammatory Effects of the Essential Oil From Fruits of Zanthoxylum coreanum Nakai

Guo

Park

et al. 2018

Front. Pharmacol.

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Zanthoxylum coreanum Nakai is a rare shrub which grows in Korea and China. Pericarp of Z. coreanum has been used as a crude medicine, but there are few researches about the pharmacologic activities. The present study was designed to investigate the anti-allergic inflammatory activities of the essential oil from fruits of Zanthoxylum coreanum Nakai (ZCO). Our findings showed that ZCO inhibited both the IgE-antigen complex or PMA/A23187-induced β-hexosaminidase release and IL-4 production dose-dependently in RBL-2H3 mast cells, and confirmed that ZCO at the tested concentrations did not show cytotoxicity to RBL-2H3 cells by MTS assay. Additionally, we found that ZCO showed the significant inhibition on LPS-induced overproduction of TNF-α, IL-6 and NO. Consistently, the protein levels of iNOS and COX-2 were also remarkably decreased by ZCO treatment. Herein, Our mechanistic studies revealed that ZCO significantly suppressed the activation of transcription factor NF-κB in PMA-activated 293T cells, and further inhibited NF-κB p65 translocation into the nucleus in LPS-stimulated RAW264.7 cells. Further investigation identified that ZCO down-regulated LPS-induced phosphorylation of MAPK (JNK, ERK, and p38) signal pathway. For incremental research, we established an DNCB-induced atopic dermatitis model in BALB/c mice, and found that ZCO remarkably inhibited DNCB-induced ear swelling and AD-like symptoms. Based on these findings, ZCO is suggested to have a therapeutic potential for the allergic inflammatory diseases.

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Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation

Cited by 29 publications

References 57 publications

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells

Anti-allergic Inflammatory Effects of the Essential Oil From Fruits of Zanthoxylum coreanum Nakai

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