For a smooth curve γ, we define its elastic energy as E(γ) = 1 2 γ k 2 (s)ds where k(s) is the curvature. The main purpose of the paper is to prove that among all smooth, simply connected, bounded open sets of prescribed area in R 2 , the disc has the boundary with the least elastic energy. In other words, for any bounded simply connected domain Ω, the following isoperimetric inequality holds:The analysis relies on the minimization of the elastic energy of drops enclosing a prescribed area, for which we give as well an analytic answer.