Drilling and completing wells in deep salt stratum are technically challenging and costing, as when serving in an incomplete borehole in deep salt formation, well casing runs a high risk of collapse. To quantitatively calculate casing remaining strength under this harsh condition, a three-dimensional mechanical model is developed; then a computational model coupled with interbed salt rock-defective cement-casing and HPHT (high pressure and high temperature) is established and analyzed using multiphysics coupling FEM (finite element method); furthermore, open wellbore shrinkage and casing remaining strength under varying differential conditions in deep salt formation are discussed. The result demonstrates that the most serious shrinkage occurs at the middle of salt rock, and the combination action of salt rock creep, cement defect, and HPHT substantially lessens casing remaining strength; meanwhile, cement defect level should be taken into consideration when designing casing strength in deep salt formation, and apart from the consideration of temperature on casing the effect of temperature on cement properties also cannot be ignored. This study not only provides a theoretical basis for revealing the failure mechanism of well casing in deep complicated salt formation, but also acts as a new perspective of novel engineering applications of the multiphysics coupling FEM.