Elastin in the Tumor Microenvironment

Wang, Yihong; Song, Elizabeth; Resnick, Murray B.

doi:10.1007/978-3-030-48457-6_1

Cited by 26 publications

(21 citation statements)

References 101 publications

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“…Tropoelastins are the precursors of elastin; they are bound to a chaperone when they are secreted; they are additionally modified when they come into contact with mature elastin fibers, when then chemically transform into elastin chains. Lack of elastin in the ECM can lead to cutis laxa and Williams syndrome (34)(35)(36).…”

Section: Elastinmentioning

confidence: 99%

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Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer

Zhao

Zheng

et al. 2021

Front. Oncol.

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Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of breast cancer (BC). The ECM comprises of highly variable and dynamic components. Compared with normal breast tissue under homeostasis, the ECM undergoes many changes in composition and organization during BC progression. Induced ECM proteins, including fibrinogen, fibronectin, hyaluronic acid, and matricellular proteins, have been identified as important components of BC metastatic cells in recent years. These proteins play major roles in BC progression, invasion, and metastasis. Importantly, several specific ECM molecules, receptors, and remodeling enzymes are involved in promoting resistance to therapeutic intervention. Additional analysis of these ECM proteins and their downstream signaling pathways may reveal promising therapeutic targets against BC. These potential drug targets may be combined with new nanoparticle technologies. This review summarizes recent advances in functional nanoparticles that target the ECM to treat BC. Accurate nanomaterials may offer a new approach to BC treatment.

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Section: Elastinmentioning

confidence: 99%

“…Studies have shown that elastin-derived peptides have numerous biological activities in cancer cells and their surrounding stroma (36). They enhance tumor cell migration and stromal invasion (39,40).…”

Section: Elastinmentioning

confidence: 99%

Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer

Zhao

Zheng

et al. 2021

Front. Oncol.

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“…It regulates several types of cancer cells by activating a multiple-step cell apoptosis process 24,25 . ELN encodes the elastin protein, which is a key protein in the tumor microenvironment 26 . Moreover, the protein encoded by the CHGA gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins 27 .…”

Section: Discussionmentioning

confidence: 99%

An Immune-related Signature Predicted Survival in Patients With Kidney Papillary Cell Carcinoma

Shen

Wang

Chen

et al. 2021

Preprint

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Immune-related genes are important factors in tumor progression. The main aim of this study was to identify the immune-related genes in Kidney papillary cell carcinoma (pRCC) patients. We downloaded RNAseq data and clinical information of pRCC patients from the TCGA database and retrieved the immune-related genes list from Immport. From the data, we mined out 2468 differential expression genes (DEGs) and 183 immune-related DEGs. Four hub DEGs (NTS, BIRC5, ELN, and CHGA) were identified after conducting Cox analysis and LASSO analysis. Moreover, the prognostic value of the signature based on 4 hub DEGs was verified using Kaplan-Meier analysis (P=0.0041 in the training set and p=0.021 in the test set) and ROC analysis (AUC: 0.957 in 1 year, 0.965 in 2 years, and 0.901 in 3 years in the training set, and 0.963 in 1 year, 0.898 in 2 years, and 0.742 in 3 years in the test set). Furthermore, we found that the high-risk score group had a higher percentage of B cells in the immune component, a higher expression of immune-related genes (CTLA4, LAG3, PDCD1LG2, and TIGIT), and a better immunotherapy response.

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“…Collagen fibrils are often found together with elastin and fibulin containing elastic fibrils [25], which, due to their reversible elasticity, allow the resilience of the ECM. Interestingly, most of the body's elastin is formed pre-and early postnatally but hardly in the adult body [26].…”

Section: The Extracellular Matrix As a Key Component Of The Tmementioning

confidence: 99%

“…Interestingly, most of the body's elastin is formed pre-and early postnatally but hardly in the adult body [26]. However, some cancer entities stimulate and reinitiate elastin production and deposition, which is known as elastosis [25]. Similarly noteworthy, elastin degradation peptides (EDPs) are released in the TME, which stimulate tumor cell growth and progression via different receptors [27] (Figure 2).…”

Section: The Extracellular Matrix As a Key Component Of The Tmementioning

confidence: 99%

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Niland

Eble

2020

IJMS

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The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs.

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Elastin in the Tumor Microenvironment

Cited by 26 publications

References 101 publications

Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer

Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer

An Immune-related Signature Predicted Survival in Patients With Kidney Papillary Cell Carcinoma

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

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