Elateriospermum tapos Yoghurt as a Therapeutic Intervention for Obesity-Associated Cognitive Impairments and Anxiety-like Behaviour in a High Fat Diet Maternal Obese Rat Model

Naomi, Ruth; Teoh, Soo Huat; Rusli, Rusydatul Nabila Mahmad; Embong, Hashim; Bahari, Hasnah; Kumar, Jaya

doi:10.3390/nu15102312

Cited by 4 publications

(1 citation statement)

References 55 publications

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“…The preliminary study has identified that there are 64 bioactive compounds in E. tapos yogurt (Supplementary Table S1) [13,14]. These are the three selected compounds Scropolioside A, Flazin, and Medicagol which have been identified as potential bioactive compounds that fulfill the necessary criteria for drug screening (ADME), as shown in Table 2.…”

Section: Selection Of Potential Bioactive Compoundsmentioning

confidence: 99%

Analyzing Active Compounds in Elateriospermum tapos Yogurt for Maternal Obesity: A Network Pharmacology and Molecular Docking Study

Naomi,

Teoh,

Embong

et al. 2023

Foods

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Maternal obesity, characterized by an elevated body mass index (BMI) during pregnancy, is known to have adverse effects on the offspring. However, a recent study suggests that Elateriospermum tapos (E. tapos) yogurt may hold potential in mitigating excessive weight retention post-pregnancy. Thus, this study aims to employ network pharmacology to explore the pharmacological effects of the bioactive compounds present in E. tapos yogurt against maternal obesity. Initially, a screening process is conducted to identify the bioactive compounds in E. tapos yogurt, followed by the prediction of potential gene targets for these compounds using Swiss Target Prediction and the SuperPred databases. Maternal obesity-associated genes are sourced from the OMIM, DisGeNet, and GeneCards databases. The interaction between the identified compounds and maternal obesity genes is established via protein–protein interaction analysis, gene ontology examination, and KEGG pathway analysis. To validate the results, molecular docking studies are conducted using AutoDock Tools software. The findings reveal that out of the 64 compounds analyzed, three meet the screening criteria, resulting in a total of 380 potential gene targets. Among these targets, 240 are shared with maternal obesity-related genes. Further analysis demonstrates the favorable affinity of these active compounds with key targets, linking them to biological processes involving protein phosphorylation, inflammation, as well as the pathways related to lipid metabolism, atherosclerosis, and the other signaling pathways. In conclusion, this study provides valuable insights into the potential pharmacological effects of the bioactive compounds found in E. tapos yogurt against maternal obesity. These findings open avenues for further exploration and potential therapeutic interventions targeting maternal obesity.

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Section: Selection Of Potential Bioactive Compoundsmentioning

confidence: 99%

Analyzing Active Compounds in Elateriospermum tapos Yogurt for Maternal Obesity: A Network Pharmacology and Molecular Docking Study

Naomi,

Teoh,

Embong

et al. 2023

Foods

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Anti-obesogenic effects of plant natural products: A focus on Korean traditional foods

Das,

Ortega,

Gonçalves

et al. 2024

Trends in Food Science & Technology

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Inflammatory mediator contributes to leptin resistance and obesity in craniopharyngioma

Xiao,

Wu,

Liu

et al. 2024

The FASEB Journal

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Obesity presents a significant challenge in managing patients with craniopharyngioma (CP). Cyst fluid (CF), rich in inflammatory mediators, is implicated in CP‐related obesity, though the precise mechanism remains unclear. This study investigated the impact of CF or C‐X‐C motif chemokine ligand‐1 (CXCL1) injections on body weight, Lee index, plasma lipid profiles, hepatic lipid accumulation, leptin levels, NF‐κB pathway, the suppressor of cytokine signaling 3 (SOCS3) expression, and leptin sensitivity in rats. Bioinformatics was employed to identify differentially expressed genes (DEGs) between CF/CXCL1‐treated and control SY5Y cells, as well as to confirm enriched pathways. Western blotting was used for experimental validation, including the effects of sodium salicylate (SS) on leptin sensitivity in SY5Y cells. Injecting CF or CXCL1 into the brain, without hypothalamic damage, led to increased body weight, Lee index, and hepatic lipid accumulation in rats, alongside elevated fasting blood glucose, triglycerides, and total cholesterol, while high‐density lipoprotein cholesterol levels decreased. Additionally, CF and CXCL1 could induce elevated leptin levels, a higher leptin‐to‐body weight ratio, and resistance to exogenous leptin by activating the NF‐κB pathway and upregulating the expression of SOCS3 in rats. Further validation confirmed that CF and CXCL1 suppress leptin signaling by activating the NF‐κB pathway and upregulating SOCS3. Moreover, SS mitigated the inhibitory effects of CF or CXCL1 on leptin signaling, preserving leptin sensitivity in SY5Y cells. These results highlight the obesogenic role of CF and CXCL1, offering insights into the development of morbid obesity through inflammatory factor‐mediated leptin resistance, independent of hypothalamic damage. SS may serve as a promising therapeutic approach for CP‐associated obesity, though additional clinical studies are necessary to confirm its efficacy.

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Elateriospermum tapos Yoghurt as a Therapeutic Intervention for Obesity-Associated Cognitive Impairments and Anxiety-like Behaviour in a High Fat Diet Maternal Obese Rat Model

Cited by 4 publications

References 55 publications

Analyzing Active Compounds in Elateriospermum tapos Yogurt for Maternal Obesity: A Network Pharmacology and Molecular Docking Study

Analyzing Active Compounds in Elateriospermum tapos Yogurt for Maternal Obesity: A Network Pharmacology and Molecular Docking Study

Anti-obesogenic effects of plant natural products: A focus on Korean traditional foods

Inflammatory mediator contributes to leptin resistance and obesity in craniopharyngioma

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