Elderly women: Homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism)

Chmurzyńska, Agata; Malinowska, Anna M.; Twardowska-Rajewska, Jolanta; Gawecki, J

doi:10.1016/j.nut.2012.09.015

Cited by 32 publications

(26 citation statements)

References 32 publications

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“…Many previous studies have explored the relationship between the MTHFR C677T polymorphism and serum or plasma lipid profiles in humans, with some indicating that the T allele was associated with unfavourable lipid profiles [8–11, 17, 36–39], whereas the others reported null association [40–43]. An interesting study by Zhang et al indicated that the MTHFR 677 T allele significantly increases the serum levels of TC and LDL-C in both Chinese Bai Ku Yao and Han populations [10].…”

Section: Discussionmentioning

confidence: 99%

“…An interesting study by Zhang et al indicated that the MTHFR 677 T allele significantly increases the serum levels of TC and LDL-C in both Chinese Bai Ku Yao and Han populations [10]. Among Polish elderly women, the MTHFR 677CT/TT genotypes were associated with higher TC and lower HDL-C levels as compared with CC genotype [36]. According to Huang et al [39], hyperlipidemia patients with MTHFR 677CT/TT genotypes had higher TG concentrations than those with CC genotype.…”

Section: Discussionmentioning

confidence: 99%

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Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

et al. 2016

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BackgroundLittle is known regarding the interactions of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with overweight/obesity on serum lipid profiles. The aim of the current study was to explore interactions between the two polymorphisms and overweight/obesity on four common lipid levels in a Chinese Han population and further to evaluate whether these interactions exhibit gender-specificity.MethodsA total of 2239 participants (750 females and 1489 males) were enrolled into this study. The genotypes of the MTHFR C677T and MTRR A66G were determined by a TaqMan assay. Overweight and obesity were defined as a body mass index between 24 and 27.99 and ≥ 28 kg/m2, respectively. The interactions were examined by factorial design covariance analysis, and further multiple comparisons were conducted by Bonferroni correction.ResultsThere was no significant difference in the genotypic and allelic frequencies between females and males (MTHFR 677 T allele: 54.47 % for females and 54.40 % for males; MTRR 66G allele: 24.73 % for females and 24.71 % for males). Interaction between the MTHFR C677T polymorphism and overweight/obesity on serum triglyceride levels, and interaction between the MTRR A66G polymorphism and overweight/obesity on serum high-density lipoprotein cholesterol levels were detected in women (P = 0.015 and P = 0.056, respectively). For female subjects with overweight/obesity, the serum triglyceride levels in MTHFR 677TT genotype [1.09 (0.78–1.50) mmol/L] were significantly higher as compared with MTHFR 677CC genotype [0.90 (0.60–1.15) mmol/L, P = 0.007], and the MTRR 66GG genotype carriers had higher serum high-density lipoprotein cholesterol levels than those with MTRR 66AG genotype (1.46 ± 0.50 vs. 1.19 ± 0.31 mmol/L, P = 0.058). Furthermore, in male subjects with overweight/obesity, the MTHFR 677CT genotype carriers had higher low-density lipoprotein cholesterol levels than those with MTHFR 677TT genotype (2.96 ± 1.07 vs. 2.74 ± 0.88 mmol/L, P = 0.015).ConclusionsOur results indicate that there exist interactive effects of the MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on some lipid traits in Chinese Han population, and the effects were gender-specific.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

et al. 2016

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“…A question of whether this variant is favorable or deleterious for Bama long-lived individuals therefore emerges. According to most but not all reported data, MTHFR 677 T genotypes have been linked to unfavorable lipid profiles, including greater concentrations of TC, TG, and LDL-C [18,23-25] and lower level of HDL-C [26,27], all known risk factors for cardiovascular and metabolic diseases. Herein, the female but not male T-allele carriers in the pooled population and in LG presented greater level of TC, TG and LDL-C than did T noncarriers (Table 3 and Table 5), in agreement with prevailing data as aforementioned, indicating that MTHFR 677 T genotypes may play detrimental rather than beneficial role in lipid modulation and survivorship.…”

Section: Discussionmentioning

confidence: 99%

Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation

Chen

Liu

et al. 2014

Lipids Health Dis

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BackgroundVariants in the Methylenetetrahydrofolate reductase (MTHFR) gene may result in a lowered catalytic activity and associate with subsequent elevated serum homocysteine (Hcy) concentration, abnormal DNA synthesis and methylation, cardiovascular risk, and unhealthy aging. Several investigations on the relationship of MTHFR C677T polymorphism with serum lipid profile and longevity have been conducted in some populations, but the findings remain mixed. Herein, we sought to look at the association between MTHFR C677T and lipid profile in a longevous cohort in Bama, a well-known home of longevity in China.MethodsGenotyping of MTHFR C677T was undertaken in 516 long-lived inhabitants (aged 90 and older, long-lived group, LG) and 493 healthy controls (aged 60–75, non-long-lived group, non-LG) recruited from Bama area. Correlation between MTHFR genotypes and lipids was then evaluated.ResultsT allele and TT genotype were significantly more prevalent in LG (P = 0.001 and 0.002, respectively), especially in females, than in non-LG. No difference in the tested lipid measures among MTHFR C677T genotypes was observed in LG, non-LG and total population (P > 0.05 for all). However, female but not male T carriers exhibited higher TC and LDL-C levels than did T noncarriers in the total population and in LG after stratification by sex (P < 0.05 for each). These differences did not however remain through further subdivision by hyperlipidemia and normolipidemia.ConclusionThe higher prevalence of MTHFR 677 T genotypes and its modest unfavorable impact on lipids in Bama long-lived individuals may imply an existence of other protective genotypes which require further determination.

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“…It may be related to renal dysfunction, dialysis adequacy, the type of dialysis membrane and uremia basic diseases, genetic and other factors [6-9]. Apolipoprotein E (ApoE) is an important component of very low-density lipoprotein (VLDL), high-density lipoprotein (HDL) and chylomicrons, which may play an important role in lipid metabolism [10-12]. Recently, an interesting study demonstrated that triacylglycerol (TAG) hydrolysis mediated by lipoprotein lipase in VLDL is accompanied by the release of surface material containing phospholipids, free cholesterol and ApoE and ApoCs (CII and CIII).…”

Section: Introductionmentioning

confidence: 99%

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Wang¹,

Wang

et al. 2017

J Clin Med Res

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BackgroundThe aim was to investigate the clinical characteristics of lipid metabolism and the effect of apolipoprotein E (ApoE) gene polymorphism on lipid metabolism in hemodialysis patients.MethodsThe serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), ApoA1, ApoB, ApoE and lipoprotein Lp(a) were detected by polymerase chain reaction-restriction fragment length (PCR-RFLP).ResultsThe level of serum TG was significantly increased and the level of HDLC was significantly decreased in hemodialysis patients. Serum TG level was 33% higher than normal, and HDLC was 10.4% less than normal. The correlation analysis showed that TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. The incidence of hypertension in hemodialysis patients was 73.6% and cardiovascular disease was 25%. The level of TG in the cardiovascular disease group was significantly higher than that in the non-cardiovascular disease group, and there was no significant difference between the hypertensive group and the non-hypertensive group. ApoE gene polymorphism test showed that the frequency of ApoE genotype ε3/3 and allele ε3 was the highest in hemodialysis patients, and the levels of TC, TG and LDLC were higher in ApoE genotype ε3/4 + ε4/4.ConclusionThe levels of serum TG and ApoB were significantly increased in patients with hemodialysis, and HDLC and other indexes were significantly decreased. The level of TG in patients with cardiovascular complications was significantly higher than in patients without complications. TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. Hemodialysis patients who had ApoE allele ε4 are prone to lipid metabolism disorders.

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Elderly women: Homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism)

Cited by 32 publications

References 32 publications

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population

Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

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