Elderly Women With Human Immunodeficiency Virus Infection: Is There an Effect of the Virus on Neuropsychological Profile?

Sorlini, M.L.; Focà, Emanuele; Motta, Davide; Salvi, Andrea Peserico Stecchini Negri De; Compostella, Silvia; Brianese, Nigritella; Ferraresi, Alice; Casari, Salvatore; Romanelli, Giuseppe; Castelli, Francesco; Quiros-Roldan, Eugenia

doi:10.1111/jgs.12625

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…The results presented above advance previous findings that adults and older adults with HIV evidence significantly poorer performance in cognitive domains of psychomotor speed, memory, visuoconstruction, and executive functioning when compared to seronegative adults (Fazeli et al, 2014; Sorlini et al, 2014). Global cognitive functioning in the HIV cohort was also significantly poorer than the age-matched HIV− control group.…”

Section: Discussionsupporting

confidence: 87%

Neuropsychological profiles of adults and older adults with HIV

Cassimjee

Motswai

2016

South African Journal of Psychology

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Section: Discussionsupporting

confidence: 87%

Neuropsychological profiles of adults and older adults with HIV

Cassimjee

Motswai

2016

South African Journal of Psychology

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“…As long as HAART is remarkably increasing life expectancy of HIV-infected individuals, a growing concern arises about the possibility of a greater incidence of neurocognitive impairment in elderly HIV-infected patients when compared to the age-matched general population [ 29 ]. In a previous study realized in our Center [ 30 ], we observed a worse cognitive performance in elderly HIV-infected women when compared to age-matched HIV-negative women. These patients presented a subcortical cognitive profile of executive dysfunction, slowing speed of processing, and deficient verbal learning, even if virologically suppressed.…”

Section: Discussionmentioning

confidence: 63%

Screening for Neurocognitive Impairment in HIV-Infected Individuals at First Contact after HIV Diagnosis: The Experience of a Large Clinical Center in Northern Italy

Focà

Magro

Motta

et al. 2016

IJMS

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Neurocognitive disorders are emerging, probably underestimated, complications in HIV-infected people. The aim of the study was to assess neurocognitive profiles of newly detected HIV-infected patients. We performed an observational retrospective single-cohort study. Illiterates and patients with neurologic symptoms or previous psychiatric diagnosis were excluded. Neuropsychological profiles were assessed using a validated battery of neuropsychological tests. We included 206 patients; with males representing the majority of them (85%). Risk factors for HIV acquisition were unprotected sexual intercourse (homo/bisexual in 39.8% and heterosexual in 60.2%). Thirty-nine patients (18.9%) were previous injection drug users, while 41 (19.9%) were alcohol abusers. Mean education was 11.1 years (SD—standard deviation—3.7). A high prevalence of HIV-associated neurocognitive disorders (HAND, 47.1%) was present in HIV-infected patients: particularly, asymptomatic neurocognitive impairment (ANI) was found in 30.6%, mild neurocognitive disorder (MND) in 15% and HIV-associated dementia (HAD) in 1.5%. Male gender, low degree of education, AIDS diagnosis and gepatitis B virus (HBV) co-infection were factors independently associated with HAND in a multivariable logistic regression model. Our data suggest that patient-specific factors and AIDS diagnosis have a certain kind of impact in HAND occurrence. A complete neuropsychological screening must be recommended in all patients at HIV-infection diagnosis.

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“… 80 , 97 , 99 , 102 – 105 However, other studies have failed to replicate this finding. 27 , 82 , 99 , 102 , 106 , 107 Depressive symptoms are also more likely to occur in women who are experiencing menopausal symptoms 94 , 102 , 108 – 110 and have been associated with reduced quality of life, 25 , 111 a negative attitude towards menopause, 28 , 112 and decreased adherence to therapy. 113 , 114 …”

Section: Impact Of Hiv Infection On Menopausementioning

confidence: 99%

“… 115 , 116 Studies have suggested that compared to men, women with HIV are more likely to have lower education levels and increased difficulty accessing ART, which may result in their being more vulnerable to the development of HIV-associated neurological disorders and dementia. 107 , 116 , 117 In a study of 41 women (20 HIV-positive and 21 HIV-negative) in Italy aged 65 years and older, women with HIV had worse performance on tests of executive function, processing speed, and verbal learning than age-matched, HIV-negative controls. 107 Depression and anxiety can exacerbate these cognitive changes.…”

Section: Impact Of Hiv Infection On Menopausementioning

confidence: 99%

“… 107 , 116 , 117 In a study of 41 women (20 HIV-positive and 21 HIV-negative) in Italy aged 65 years and older, women with HIV had worse performance on tests of executive function, processing speed, and verbal learning than age-matched, HIV-negative controls. 107 Depression and anxiety can exacerbate these cognitive changes. 99 , 115 , 116 In a study of 708 HIV-positive and 278 HIV-negative women living in the USA, women with HIV had a poorer performance on tests of verbal learning than those without HIV.…”

Section: Impact Of Hiv Infection On Menopausementioning

confidence: 99%

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Perspectives on menopause and women with HIV

Andany

Kennedy

Aden

et al. 2016

IJWH

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Since the implementation of effective combination antiretroviral therapy, HIV infection has been transformed from a life-threatening condition into a chronic disease. As people with HIV are living longer, aging and its associated manifestations have become key priorities as part of HIV care. For women with HIV, menopause is an important part of aging to consider. Women currently represent more than one half of HIV-positive individuals worldwide. Given the vast proportion of women living with HIV who are, and will be, transitioning through age-related life events, the interaction between HIV infection and menopause must be addressed by clinicians and researchers. Menopause is a major clinical event that is universally experienced by women, but affects each individual woman uniquely. This transitional time in women’s lives has various clinical implications including physical and psychological symptoms, and accelerated development and progression of other age-related comorbidities, particularly cardiovascular disease, neurocognitive dysfunction, and bone mineral disease; all of which are potentially heightened by HIV or its treatment. Furthermore, within the context of HIV, there are the additional considerations of HIV acquisition and transmission risk, progression of infection, changes in antiretroviral pharmacokinetics, response, and toxicities. These menopausal manifestations and complications must be managed concurrently with HIV, while keeping in mind the potential influence of menopause on the prognosis of HIV infection itself. This results in additional complexity for clinicians caring for women living with HIV, and highlights the shifting paradigm in HIV care that must accompany this aging and evolving population.

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Elderly Women With Human Immunodeficiency Virus Infection: Is There an Effect of the Virus on Neuropsychological Profile?

Cited by 4 publications

References 7 publications

Neuropsychological profiles of adults and older adults with HIV

Neuropsychological profiles of adults and older adults with HIV

Screening for Neurocognitive Impairment in HIV-Infected Individuals at First Contact after HIV Diagnosis: The Experience of a Large Clinical Center in Northern Italy

Perspectives on menopause and women with HIV

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