Electric Current Transmission Through Tissues of the Vestibular Labyrinth of a Patient: Perfection of the Vestibular Implant

Demkin, V. P.; Shchetinin, P. P.; Melnichuk, S. V.; Kingma, Herman; Berg, Raymond van de; Pleshkov, Maksim; Starkov, Dmitrii

doi:10.1007/s11182-018-1318-5

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Statistical differences between stimulation intensity with this electrode configuration also suggest different current pathways in the head. Considering the tissue impedance, selective stimulation of each canal seems not feasible with a noninvasive approach (Demkin et al., 2018). We presume that the electrical field generated by the dipole orientation in each SCC configuration will influence the desired canal and adjacent sensory and neural structures.…”

Section: Discussionmentioning

confidence: 99%

A transient decrease in heart rate with unilateral and bilateral galvanic vestibular stimulation in healthy humans

Pliego

Vega

Gómez

et al. 2021

Eur J of Neuroscience

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The study of cardiovascular function with galvanic vestibular stimulation has provided evidence on the neural structures that are involved in the vestibulo-autonomic reflex. This study determined if the effect on heart rate using galvanic vestibular stimulation persists after provoking a sympathetic response and if this response differs when using unilateral or transmastoid (bilateral) stimulation. We analysed heart rate and heart rate variability using unilateral and transmastoid galvanic vestibular stimulation combined with cardiovascular reflex evoked by postural change in 24 healthy human subjects. Three electrode configurations were selected for unilateral stimulation considering the anatomical location of each semicircular canal. We compared recordings performed in seated and standing positions, and with unilateral and transmastoid stimulation. With subjects seated, a significant transient decrease in heart rate was observed with unilateral stimulation. With transmastoid stimulation, heart rate decreased in both seated and standing positions. Average intervals between normal heartbeats recorded with stimulation resemble parasympathetic cardiac function induced by auricular vagal nerve stimulation. Our results indicate that unilateral stimulation does not eliminate the natural heart rate increase caused by orthostatic hypotension. In contrast, transmastoid stimulation provoked a transient reduction in heart rate, even when subjects were standing. These responses should be considered while performing experiments with galvanic vestibular stimulation and subsequent effects in cardiac regulation mechanisms.

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Section: Discussionmentioning

confidence: 99%

A transient decrease in heart rate with unilateral and bilateral galvanic vestibular stimulation in healthy humans

Pliego

Vega

Gómez

et al. 2021

Eur J of Neuroscience

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“…In recent years, several distributed parameter models (Hayden et al 2012, Marianelli et al 2015, Handler et al 2017 together with lumped parameter models (Demkin et al 2018(Demkin et al , 2020 have been proposed for investigation of the current propagation in the tissues of the human and animal inner ear to optimize the VI stimulation. The abovementioned distributed parameter models mainly consider the interelectrode space to be purely resistive.…”

Section: Introductionmentioning

confidence: 99%

Fitting the determined impedance in the guinea pig inner ear to Randles circuit using square error minimization in the range of 100 Hz to 50 kHz

Pleshkov

D'Alessandro

Светлик

et al. 2022

Biomed. Phys. Eng. Express

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Objective. A number of lumped and distributed parameter models of the inner ear have been proposed in order to improve the vestibular implant stimulation. The models should account for all significant physical phenomena influencing the current propagation: electrical double layer (EDL) and medium polarization. The electrical properties of the medium are reflected in the electrical impedance, therefore the aim of this study was to measure the impedance in the guinea pig inner ear and construct its equivalent circuit. Approach. The electrical impedance was measured from 100 Hz to 50 kHz between a pair of platinum electrodes immersed in saline solution using sinusoidal voltage signals. The Randles circuit was fitted to the measured impedance in the saline solution in order to estimate the EDL parameters (C, W, and Rct) of the electrode interface in saline. Then, the electrical impedance was measured between all combinations of the electrodes located in semicircular canal ampullae and the vestibular nerve in the guinea pig in vitro. The extended Randles circuit considering the medium polarization (Ri, Re, Cm) together with EDL parameters (C, Rct) obtained from the saline solution was fitted to the measured impedance of the guinea pig inner ear. The Warburg element was assumed negligible and was not considered in the guinea pig model. Main results. For the set-up used, the obtained EDL parameters were: C=27.09*10-8 F, Rct=18.75 kΩ. The average values of intra-, extracellular resistances, and membrane capacitance were Ri=4.74 kΩ, Re=45.05 kΩ, Cm=9.69*10-8 F, respectively. Significance. The obtained values of the model parameters can serve as a good estimation of the EDL for modelling work. The EDL, together with medium polarization, plays a significant role in the electrical impedance of the guinea pig inner ear, therefore, they should be considered in electrical conductivity models to increase the credibility of the simulations.

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Electrophysical Properties and Determination of the Impedance of Vestibular Labyrinth Tissues

et al. 2019

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Electric Current Transmission Through Tissues of the Vestibular Labyrinth of a Patient: Perfection of the Vestibular Implant

Cited by 5 publications

References 15 publications

A transient decrease in heart rate with unilateral and bilateral galvanic vestibular stimulation in healthy humans

A transient decrease in heart rate with unilateral and bilateral galvanic vestibular stimulation in healthy humans

Fitting the determined impedance in the guinea pig inner ear to Randles circuit using square error minimization in the range of 100 Hz to 50 kHz

Electrophysical Properties and Determination of the Impedance of Vestibular Labyrinth Tissues

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