“…To enhance localization of Photofrin to tumors, the tumor-localizing graft copolymer poly (ethylene glycol)-grafted poly (l-lysine) have been developed, which interact with Photofrin through ionic and hydrophobic interactions [29]. Electric field-assisted delivery of photofrin, electroporation, to the breast adenocarcinoma cells (MCF-7) and normal Chinese hamster ovary cells (CHO) has been found to enhance cellular uptake of Photofrin, which reduces effective dose and exposure time diminishing side effects of the therapy [30]. The efficacy of PDT is also affected by combining with some other drugs, such as Celecoxib, Dihydroartemisinin (DHA), and microRNAs (miRs), which regulate either the signaling pathway or gene expression in some cancer cell lines [31,32,33].…”