Electrical activity across human foetal small intestine associated with absorption processes.

Levin, Roy J.; Koldovský, Otakar; Hošková, J.; Jirsová, V.; Uhér, J

doi:10.1136/gut.9.2.206

Cited by 46 publications

(18 citation statements)

References 25 publications

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“…Glucose absorption is the final common pathway for the assimilation of almost all dietary carbohydrates. Electrogenic glucose transport has been demonstrated in 12-week-old fetuses [2,3]. The potential difference generated by glucose transfer appears to be greater in fetuses of 21 weeks gestational age than in fetuses of 14.5 weeks gestational age [3].…”

Section: Introductionmentioning

confidence: 93%

“…Electrogenic glucose transport has been demonstrated in 12-week-old fetuses [2,3]. The potential difference generated by glucose transfer appears to be greater in fetuses of 21 weeks gestational age than in fetuses of 14.5 weeks gestational age [3]. Whether glucose absorption increases with increasing gestational age after this time has not been studied directly.…”

Section: Introductionmentioning

confidence: 99%

“…Although glucose absorption has been demonstrated in 12-week-old fetuses by measuring electrical activity (presumably generated by glucose flux), direct measurements have not been made in older gestational age infants [2,3]. McNeish et al [20] measured potential differences generated by glucose infusion into the proximal intestine of premature and term infants.…”

Section: Glucose Absorption Kineticsmentioning

confidence: 99%

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In vivo Measurements of Glucose Absorption in Preterm Infants

Shulman¹

1999

Neonatology

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Few data are available regarding the kinetics of glucose absorption in the preterm infant. In order to ascertain the kinetics of glucose absorption in the premature infant and how rate of infusion and concentration affect absorption, jejunal glucose absorption kinetics were measured in 16 preterm infants by infusing 1, 10, and 100 mM glucose solutions in random order. Seventeen infants were perfused with glucose (100 μmol/min) by infusing 67 mM glucose at 1.5 ml/min and 133 mM glucose at 0.75 ml/min to determine the effect of changes in rate of infusion vs. concentration on glucose absorption. K_m and V_max were related to postnatal age. K_m was correlated inversely with the percentage of feedings received as human milk. Antenatal administration of glucocorticoids appeared to increase V_max. The higher infusion rate resulted in greater glucose absorption than the higher concentration glucose solution. Conclusions: The characteristics of glucose absorption in the preterm infant change with age and are affected by diet, glucocorticoids, and the method of infusion. These data have implications for the feeding of preterm infants.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Glucose Absorption Kineticsmentioning

confidence: 99%

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In vivo Measurements of Glucose Absorption in Preterm Infants

Shulman¹

1999

Neonatology

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“…Specific transport of different amino acids was found in the intestine of the 12-week-old fetus (10,14).…”

Section: Intestinal Functionsmentioning

confidence: 97%

“…Both aerobic and anaerobic transport systems for glucose are present in the intestine of 3-month-old human fetuses (10,14). Those in the ileum do not further increase, but transport capacity in the jejunum has doubled by the 5th month ( 10).…”

Section: Intestinal Functionsmentioning

confidence: 99%

Development of Digestive and Absorptive Function in the Human Fetus

Shmerling¹

1976

Ann Nutr Metab

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In the mature human newborn infant, only pancreatic α-amylase shows a very low but highly inducible activity. Other digestive enzymes, although not yet at adult levels, increase rapidly with age. Intestinal absorptive functions develop already during early and mid-pregnancy and are mostly at adult levels in the newborn infant. Fat absorption is usually low in the premature infant and increases rapidly during the first month.

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