Electrical and Metabolic Manifestations of Receptor and Higher-Order Neuron Activity in Vertebrate Retina

Sickel, W.

doi:10.1007/978-1-4684-8231-7_11

Cited by 44 publications

(24 citation statements)

References 18 publications

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“…In the past, the model of the isolated and superfused vertebrate retina was frequently used for the screening of drug and other toxin effects on the sensitive phototransduction and transretinal signaling [20,[46][47][48] (Figure 2). …”

Section: Transretinal Signaling Of Neuronal Networkmentioning

confidence: 99%

“…In parallel, the oxidation of NADH was accelerated (recorded as a decrease of UV-absorption at 350 nm [ Figure 3 in Sickel, 1968] [19]. In summary, these early investigations of the light effect on retinal energy metabolism lead to 3 conclusions [20]: (i) A depression of oxygen uptake or CO 2 -output for the duration of the light exposure. (ii) Transitory increases of the energy metabolism during repetitive changes of light intensity, increasing or decreasing (flickering light).…”

Section: Ex Vivo Erg Recording and Determination Of Pyridine Nucleotimentioning

confidence: 99%

“…It corresponds to an amount of energy several million-fold larger than that amount of the quanta absorbed with a single flash [20]. In 1994 it was reported that these early parallel recordings of electric field potential changes, and the absorption changes of the pyridine nucleotides may not have been taken up by the scientific readership, so that new data were measured and published carefully extending and proving the correlation between ERG-parameters and optical response at 350 nm [21].…”

Section: Quantification Of Required Oxygen and Effects Of Electron Trmentioning

confidence: 99%

“…In the rat, under normal physiological conditions, intraretinal oxygen profiles show the highest oxygen tension (more than 40 mmHg) close to the deep choroid region, and the lowest oxygen tension (5-10 mmHg) within the retinal network. An intermediate elevation (15)(16)(17)(18)(19)(20) can be found close to the deep retinal capillary layer [8]. In highly energy consuming regions, the pO 2 may be demonstrated to be low, as it is around inner segments, or high, as it would be around ganglion cells that happen to be near a blood vessel.…”

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confidence: 97%

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Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

Albanna¹,

Lüke²,

Alpdogan³

et al. 2018

New Front Ophthalmol

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Purpose: The isolated and superfused retina from vertebrates is routinely used for neurophysiological measurements of basic retinal signal generation and transduction. Such an ex vivo isolated neural network moreover represents a useful model system for the investigation of drugs and toxins and may also be helpful to elucidate molecular mechanisms of CNS diseases. The present overview aims to bring observations to the reader's attention, which, in part, have been made more than 50 years ago and were sparsely followed up upon in subsequent research, but may support the idea that the isolated bovine retina represents a useful system to investigate the physiology and pathophysiology of energy supply to neuronal tissue. Material and methods:Parallel recording of ERGs and pyridine nucleotide oxidation in the isolated and superfused vertebrate retina. The review will focus on topics, which discuss the connection between retinal electrophysiology and underlying energy metabolism.Results: Previous and present reports about (i) transretinal signaling cascades, (ii) the involvement of the pharmacoresistant Cav2.3 / R-type calcium channel in transretinal signaling and (iii) data about the retinal oxygen demands and concentration in different layers are collected, which elucidate that the retina may be used as a cerebral surrogate model in different research areas. Retinal tolerance to ischemia is several times larger than the tolerance in the remaining brain. Conclusions:The retinal energy supply through retinal vessels is regulated and controlled by neurovascular coupling. Classical retinal recording techniques and special retinal abilities in electrical-vascular coupling will be set in perspective with novel recording techniques, currently brought into clinical application for the detection of impaired neurovascular coupling after aneurysmal subarachnoid hemorrhage in the brain. The present review elucidates that important pathophysiological aspects related to the upregulation of pharmacoresistant Cav2.3 / R-type calcium channels during SAH may be investigated in the isolated vertebrate retina. Ischemic tolerance in the vertebrate retinaThe oxygen consumption of the vertebrate retina on a per gram basis has been described as higher than that of the brain [1,2]. Oxygen cannot be "stored" in tissue so that a constant and adequate supply must be guaranteed to preserve function. Metabolic dysfunction regarding to impaired vascular supply is directly reflected by retinal oxygen saturation which can be detected noninvasively by dual wavelength fundus photography [3]. Normally, the oxygen saturation in retinal vessels differs along vascular segments and is higher in the macular region than retinal periphery [4]. Many retinal diseases are caused by a dysfunction of the vascular network. Interestingly, the venous oxygen saturation in diabetic retinopathy was higher in venules draining the macular surroundings than retinal periphery that reflect specific metabolic conditions [5,6].Since a relatively unobstructed light path...

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Section: Transretinal Signaling Of Neuronal Networkmentioning

confidence: 99%

Section: Ex Vivo Erg Recording and Determination Of Pyridine Nucleotimentioning

confidence: 99%

Section: Quantification Of Required Oxygen and Effects Of Electron Trmentioning

confidence: 99%

mentioning

confidence: 97%

See 2 more Smart Citations

Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

Albanna¹,

Lüke²,

Alpdogan³

et al. 2018

New Front Ophthalmol

View full text Add to dashboard Cite

show abstract

“…A retina pode gerar espécies reativas de oxigê-nio por diversas razões: alto consumo de oxigênio (38) , possibilidade de altos níveis cumulativos de irradiação, sobretudo a luz azul e ultravioleta (13) , presença de ácidos graxos (segmentos externos dos fotorreceptores) (39) , presença de cromóforos na retina neurossensorial e EPR (40) , além do processo de fagocitose das extremidades de cones e bastonetes pelo EPR (41) .…”

Section: Geração De Espécies Reativas De Oxi-gênio Na Retinaunclassified

Conceitos atuais e perspectivas na prevenção da degeneração macular relacionada à idade

Torres¹,

Précoma²,

Maia³

et al. 2008

Rev. bras.oftalmol.

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Nutrition and the ageing eye

Carneiro¹

2015

Anti‐ageing Nutrients

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Electrical and Metabolic Manifestations of Receptor and Higher-Order Neuron Activity in Vertebrate Retina

Cited by 44 publications

References 18 publications

Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

Selected aspects of retinal signaling and energy metabolism and its perspective as a cerebral surrogate model

Conceitos atuais e perspectivas na prevenção da degeneração macular relacionada à idade

Nutrition and the ageing eye

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