Electrical Coupling between Locomotor-Related Excitatory Interneurons in the Mammalian Spinal Cord

Hinckley, Christopher A.; Ziskind-Conhaim, Lea

doi:10.1523/jneurosci.0395-06.2006

Cited by 81 publications

(104 citation statements)

References 43 publications

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“…With respect to the former point, we have recently found that Hb9 interneurones are not electronically coupled to each other, but to other, non-Hb9 interneurones (Wilson et al, 2007) which had previously been shown to have spikelets indicative of electrotonic coupling . This is in contrast to another recent study which suggested that putative Hb9 interneurones are coupled with each other (Hinckley and Ziskind-Conhaim, 2006). …”

Section: A Candidate Population Of Rhythmogenic Neurones: Hb9 Internecontrasting

confidence: 99%

Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Brownstone

Wilson

2008

Brain Research Reviews

137

122

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Despite significant advances in our understanding of pattern generation in invertebrates and lower vertebrates, there have been barriers to the application of the principles learned to the definition of networks underlying mammalian locomotion. Major difficulties have arisen in identifying spinal interneurones in preparations which allow study of neuronal intrinsic properties and the role of identified interneurones in locomotor networks. Recent genetic technologies in which selective expression of fluorescent proteins in specific populations of mouse spinal neurones have provided new avenues of investigation. In this review, we focus on the generation of locomotor rhythm and outline criteria that rhythm-generating neurones might be expected to fulfill. We then examine the extent to which a recently identified population of spinal interneurones, Hb9 interneurones, fulfill these criteria. Finally, we suggest that Hb9 interneurones could be involved in an asymmetric model of locomotor rhythmogenesis through projections of electrotonically coupled rhythmgenerating modules to flexor pattern formation half-centres. The principles learned from studying this population of interneurones have led to strategies to systematically evaluate neurones that may be involved in locomotor rhythmogenesis.

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Section: A Candidate Population Of Rhythmogenic Neurones: Hb9 Internecontrasting

confidence: 99%

Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis

Brownstone

Wilson

2008

Brain Research Reviews

137

122

View full text Add to dashboard Cite

show abstract

“…This proportion is similar to what has been shown for all ventral interneuronal populations sampled during drug-induced locomotion Tresch and Kiehn, 1999;Raastad et al, 2000;Butt et al, 2002;Wilson et al, 2005Wilson et al, , 2007Hinckley and Ziskind-Conhaim, 2006;Zhong et al, 2006) with the exception of one report in which almost 90% of Hb9-positive neurons were rhythmically active (Hinckley et al, 2005). It is possible that nonrhythmic Chx10 cells are not engaged directly in rhythmic CPG activity or that they are recruited under different speeds or patterns of locomotor activity.…”

supporting

confidence: 84%

“…In early postnatal animals, electrical coupling is also a pronounced phenomenon both between motor neurons (Chang et al, 1999;Kiehn and Tresch, 2002;Tresch and Kiehn, 2002) and interneurons (Hinckley and Ziskind-Conhaim, 2006;. Since we saw cells firing in the same phase of the locomotor cycle and observed a strong excitatory input to Chx10 neurons in their active phase, we tested for synaptic and electrical coupling between Chx10 neurons.…”

Section: Excitatory Coupling Among Chx10 Cells Is Sparsementioning

confidence: 99%

“…Since the dorsal population has a weaker expression of GFP and is anatomically separated from the Chx10-positive neurons in the ventral spinal cord, we were able to reproducibly target Chx10 neurons both in slices and in the dorsal horn-removed preparation without having to rely on secondary characteristics of the neurons (cf. Hinckley et al, 2005;Wilson et al, 2005Wilson et al, , 2007Hinckley and Ziskind-Conhaim, 2006).…”

Section: Chx10-gfp Mouse Is Useful For Studying V2a Neuronsmentioning

confidence: 99%

“…The membrane properties of the Chx10 population may therefore play a less significant role in recruiting the neurons into the network than the synaptic inputs that they receive. Moreover, rhythmogenic membrane properties (Butt et al, 2002;Wilson et al, 2005;Hinckley and Ziskind-Conhaim, 2006;Zhong et al, 2006) have been identified in other populations of rodent spinal interneurons, suggesting that they themselves do not provide a distinct electrophysiological signature. Having said this, however, it is not impossible that the distinct firing patterns observed here may correspond to uniquely molecularly defined populations since the V2a population can be further subdivided based on expression on other transcription factors than Chx10 (Dougherty et al, 2009).…”

Section: Membrane Properties Of Chx10 Neurons Are Heterogeneous Not mentioning

confidence: 99%

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