Electrical parameters for physiological His–Purkinje pacing vary by implant location in an ex vivo canine model

Mattson, Alexander R.; Mattson, Elizabeth; Mesich, Mary Lauren; Yang, Zhongping; Iaizzo, Paul A.

doi:10.1016/j.hrthm.2018.09.009

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…The arrangement of the conduction axis is thus dissimilar to the human situation in both these species. This suggests that the dog is unlikely to prove a good experimental model either for His bundle pacing, as was suggested in a recent investigation (Mattson et al, ), or for the relatively new technique of transcatheter insertion of the aortic valve.…”

Section: Discussionmentioning

confidence: 95%

The ox atrioventricular conduction axis compared to human in relation to the original investigation of sunao tawara

et al. 2019

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It was Sunao Tawara who, in 1906, established the foundations for knowledge of the arrangement of the atrioventricular conduction axis in man and other mammals. Study of the hearts of ungulates was a central part in his investigation, which assessed other species, including man. He described several subtle differences between the mammals. We have now ourselves studied the cardiac conduction tissue of the ox heart, comparing our findings with our knowledge of the arrangement in man, and providing new insights into the differences illustrated by Tawara. It is, perhaps, surprising that these differences, although subtle, have not attracted more attention. We show that the major difference is the fact that the noncoronary aortic sinus in the ox heart is mainly supported by the myocardium of the ventricular septum, whereas in the human heart the sinus, and its leaflet, are in fibrous contiguity with the aortic leaflet of the mitral valve. It is this feature that determines the difference in the arrangement of the conduction axis between the species. We also show that the emergence of the left bundle branch on the left ventricular aspect of the muscular septum is more variable than previously described. Clin. Anat. 33:383–393, 2020. © 2019 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 95%

The ox atrioventricular conduction axis compared to human in relation to the original investigation of sunao tawara

et al. 2019

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“…Furthermore, the anatomy of the HB varies among patients, potentially yielding different electrophysiological pacing profiles. Given that HBP capture may be achieved from either the atrial or ventricular side of the tricuspid annulus, there is discussion regarding the benefits and downsides of each 1 . We used direct visualization within reanimated human hearts to provide a comprehensive understanding of the anatomy central to HBP lead implantations.…”

Section: Introductionmentioning

confidence: 99%