Abstract. In atmospheric science, measurements above the surface have long been obtained by carrying instrument packages, radiosondes, aloft using balloons. Whilst occasionally used for research, most radiosondes – around one thousand are released daily – only generate data for routine weather forecasting. If meteorological radiosondes are modified to carry additional sensors, of either mass-produced commercial heritage or designed for a specific scientific application, a wide range of new measurements becomes possible. Development of add-on devices for standard radiosondes, whilst retaining the core meteorological use, is described here. Combining diverse sensors on a single radiosonde helps interpretation of findings, and yields economy of equipment, consumables and effort. A self-configuring system has been developed to allow different sensors to be easily combined, enhancing existing weather balloons and providing an emergency monitoring capability for airborne hazards. This research programme was originally pursued to investigate electrical properties of extensive layer clouds, and has expanded to include a wide range of balloon-carried sensors for solar radiation, cloud, turbulence, volcanic ash, radioactivity and space weather. For the layer cloud charge application, multiple soundings in both hemispheres have established that charging of extensive layer clouds is widespread, and likely to be a global phenomenon. This paper summarises the Christiaan Huygens medal lecture given at the 2021 European Geoscience Union meeting.