Electrical stimulation for wound healing

Balakatounis, Konstantine C

doi:10.1533/9780857093301.4.571

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Compared with other treatments, ES is suitable for various wounds, owing to the advantages of requiring no foreign objects and minimal side effects. Exogenous ES can promote the directional migration of cells and signal molecules through chemotaxis, promote the secretion of relevant growth factors, enhance the mitochondrial function, and promote various intracellular ways; thus, collagen fiber synthesis increased, the wound epithelization was accelerated, and the wound closed faster in an endogenous manner. The effectiveness of ES therapy has been confirmed on several animal and clinical studies, , and this therapy predominantly relied on specialized equipment or batteries, thereby inconveniencing medical staff and patients.…”

Section: Resultsmentioning

confidence: 99%

Two-Layered Biomimetic Flexible Self-Powered Electrical Stimulator for Promoting Wound Healing

et al. 2023

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The repair of wound damage has been a common problem in clinic for a long time. Inspired by the electroactive nature of tissues and the electrical stimulation of wounds in clinical practice, the next generation of wound therapy with self-powered electrical stimulator is expected to achieve the desired therapeutic effect. In this work, a two-layered self-powered electrical-stimulator-based wound dressing (SEWD) was designed through the on-demand integration of the bionic tree-like piezoelectric nanofiber and the adhesive hydrogel with biomimetic electrical activity. SEWD has good mechanical properties, adhesion properties, self-powered properties, high sensitivity, and biocompatibility. The interface between the two layers was well integrated and relatively independent. Herein, the piezoelectric nanofibers were prepared by P(VDF-TrFE) electrospinning, and the morphology of the nanofibers was controlled by adjusting the electrical conductivity of the electrospinning solution. Benefiting from its bionic dendritic structure, the prepared piezoelectric nanofibers had better mechanical properties and piezoelectric sensitivity than native P(VDF-TrFE) nanofibers, which can convert tiny forces into electrical signals as a power source for tissue repair. At the same time, the designed conductive adhesive hydrogel was inspired by the adhesive properties of natural mussels and the redox electron pairs formed by catechol and metal ions. It has bionic electrical activity matching with the tissue and can conduct the electrical signal generated by the piezoelectric effect to the wound site so as to facilitate the electrical stimulation treatment of tissue repair. In addition, in vitro and in vivo experiments demonstrated that SEWD converts mechanical energy into electricity to stimulate cell proliferation and wound healing. The proposed healing strategy for the effective treatment of skin injury was provided by developing self-powered wound dressing, which is of great significance to the rapid, safe, and effective promotion of wound healing.

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Section: Resultsmentioning

confidence: 99%

Two-Layered Biomimetic Flexible Self-Powered Electrical Stimulator for Promoting Wound Healing

et al. 2023

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“…The electrostimulation group had a significant lead in growth factor expression compared to the hydrogel, suggesting that the promotion of growth factor expression by electrostimulation is intrinsic to the acceleration of wound healing. Studies have shown that exogenous electrical stimulation can promote the directed migration of cells and signaling molecules through electrotaxis, promote the secretion of related growth factors through various intracellular pathways, , and promote the enhancement of mitochondrial function and many other positive effects on cells . Thus, in an endogenous way, collagen fiber synthesis can be increased, wound epithelialization can be accelerated, and wound closure can be accelerated .…”

Section: Resultsmentioning

confidence: 99%

“…In terms of growth factor expression, both the DC-GEL-PAM-3 sample group and the control group showed different degrees of positive expression. At the four time points of 3, 7, 14, and 21 d, the positive expression of growth factors in the experimental group was stronger than that of the blank directed migration of cells and signaling molecules through electrotaxis, 27 promote the secretion of related growth factors through various intracellular pathways, 30,31 and promote the enhancement of mitochondrial function 32 and many other positive effects on cells. 29 Thus, in an endogenous way, collagen fiber synthesis can be increased, wound epithelialization can be accelerated, and wound closure can be accelerated.…”

Section: Electrical Performance Testmentioning

confidence: 90%

Wearable and Flexible Hydrogels for Strain Sensing and Wound Electrical Stimulation

Zhang

Wang

et al. 2023

Ind. Eng. Chem. Res.

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Conductive hydrogels have attracted a great deal of interest in health testing and electrical stimulation therapy. To improve the inherent brittleness and stickiness of hydrogels, a multifunctional electronic skin mediated by dopamine-modified carbon nanotubes and gelatin was fabricated. In this work, a flexible, conductive, and biocompatible adhesive hydrogel was prepared directly without further processing by simply mixing dopamine-modified carbon nanotubes, gelatin, and acrylamide. Carbon nanotubes play a dominant role in the electromechanical and mechanical properties of the hydrogel. The polydopamine gives the hydrogel good and reproducible adhesion properties. At the same time, the hydrogels obtained have good sensing properties and can detect mechanically conducted signals of human motion. In addition, the hydrogels are able to act as conductive media to deliver electrical stimuli generated by poly(vinylidene fluoride-trifluoroethylene) piezoelectric membranes to accelerate wound healing. In conclusion, this work provides a feasible method to prepare hydrogel sensors with good biocompatibility, good mechanical properties, and good adhesion, which can be widely used in human motion detection, smart skin, and electrical stimulation therapy.

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Investigation of the antimicrobial effect of anodic iontophoresis on Gram-positive and Gram-negative bacteria for skin infections treatment

Viola

Dalmolin

Muñoz

et al. 2023

Bioelectrochemistry

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Electrical stimulation for wound healing

Cited by 6 publications

References 45 publications

Two-Layered Biomimetic Flexible Self-Powered Electrical Stimulator for Promoting Wound Healing

Two-Layered Biomimetic Flexible Self-Powered Electrical Stimulator for Promoting Wound Healing

Wearable and Flexible Hydrogels for Strain Sensing and Wound Electrical Stimulation

Investigation of the antimicrobial effect of anodic iontophoresis on Gram-positive and Gram-negative bacteria for skin infections treatment

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