Electrical Stimulation in Tissue Regeneration

Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin‐bioactivated conductive scaffolds

“…Furthermore, 80% of the respondents thought that bone stimulators would reduce the healing time of bone. The electrical stimulators used in clinics are mostly non‐invasive and based on either low frequency pulse electromagnetic fields or capacitive electrodes [Meng et al, 2011]. Implantable electrodes are also used but to a lesser extent.…”

Enhanced growth of neural networks on conductive cellulose-derived nanofibrous scaffolds

“…Neurons are capable of using relatively weak electrochemical signals in mV range for regulation of cellular functions. Electrical conductive scaffolds can help to transmit these essential signals between neurons, which has a positive influence on the development of neural tissue [12,13]. In earlier studies, carbon nanostructures with a wide range of conductivity values (mostly above 10 S cm -1 )…”

Neural Engineering

“…The prominent role of bioelectricity in the body makes it an attractive factor to manipulate for accelerating wound healing. External electric fi elds can infl uence ion infl ux through ionic membrane channels to affect intracellular signal transduction pathways through second messengers such as cAMP and Ca 2+ , which can in turn affect enzyme phosphorylation and alter gene expression (Meng and Zhang 2011 ). Meng et al points to several studies that document electrical stimulation infl uencing actin assembly and distribution as well as activating transmembrane channels and receptors; components identifi ed to be involved in cell migration and proliferation (Meng and Zhang 2011 ).…”

“…External electric fi elds can infl uence ion infl ux through ionic membrane channels to affect intracellular signal transduction pathways through second messengers such as cAMP and Ca 2+ , which can in turn affect enzyme phosphorylation and alter gene expression (Meng and Zhang 2011 ). Meng et al points to several studies that document electrical stimulation infl uencing actin assembly and distribution as well as activating transmembrane channels and receptors; components identifi ed to be involved in cell migration and proliferation (Meng and Zhang 2011 ). From a seminal report in 1982, Patel theorized that electrical stimulation induces the redistribution of components in the cytoplasm, activates transport and proliferative processes, and causes the electrophoretic accumulation of surface molecules that promote neurite adhesion and outgrowth (Wrobel 2013 ; ).…”