Electrical stimulation reduces smokers’ craving by modulating the coupling between dorsal lateral prefrontal cortex and parahippocampal gyrus

Yang, Lizhuang; Shi, Bin; Li, Hai; Zhang, Wei; Liu, Ying; Wang, Hongzhi; Zhou, Yanfei; Wang, Ying; Lv, Wanwan; Ji, Xuebing; Hudak, Justin; Zhou, Yifeng; Fallgatter, Andreas J.; Zhang, Xiaochu

doi:10.1093/scan/nsx055

Cited by 56 publications

(40 citation statements)

References 28 publications

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“…Namely, a diminution of craving was observed after active tDCS sessions as compared to sham but we did not observe a cumulative effect of sessions on craving diminution. The reduction of smoking craving observed after tDCS is consistent with studies showing that tDCS reduced cue-induced craving 10 , 11 , 13 , 39 and background/tonic smoking craving 10 . The distinct effects of tDCS on smoking and craving suggested distinct brain underpinnings.…”

Section: Discussionsupporting

confidence: 88%

Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues

Mondino

Luck

Grot

et al. 2018

Sci Rep

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Recent studies have shown that transcranial direct current stimulation (tDCS) may reduce craving and smoking. However, little is known regarding brain correlates of these behavioral changes. We aimed to evaluate whether 10 sessions of tDCS modulate cigarette consumption, craving and brain reactivity to smoking cues in subjects with tobacco use disorder (TUD). In a double blind parallel-arms study, 29 subjects with TUD who wished to quit smoking were randomly assigned to receive 10 sessions of either active or sham tDCS applied with the anode over the right dorsolateral prefrontal cortex (DLPFC) and a large cathode over the left occipital region. As compared to sham, active tDCS significantly reduced smoking craving and increased brain reactivity to smoking-cues within the right posterior cingulate, as measured with a functional magnetic resonance imaging event-related paradigm. However, we failed to find a significant difference between active and sham groups regarding the self-reported number of cigarettes smoked and the exhaled carbon monoxide during one month. These findings suggested that 10 sessions of tDCS over the right DLPFC may reduce craving by modulating activity within the resisting-to-smoke network but might not be significantly more effective than sham to decrease cigarette consumption.

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Section: Discussionsupporting

confidence: 88%

Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues

Mondino

Luck

Grot

et al. 2018

Sci Rep

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“…Stimulating TPJ, no matter the left or right part, shared the same mechanism of influencing the mPFC. This hypothesis is consistent with the recent network explanation of the tDCS effect …”

Section: Discussionmentioning

confidence: 92%

Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation

et al. 2020

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Modulating the temporoparietal junction (TPJ), especially the right counterpart, shows promises in enhancing social cognitive ability. However, it is ambiguous whether the functional lateralization of TPJ determines people's responsiveness to brain stimulation. Here, this issue is investigated with an individual difference approach. Forty‐five participants attended three sessions of transcranial direct current stimulation (tDCS) experiments and one neuroimaging session. The results support the symmetric mechanism of left and right TPJ stimulation. First, the left and right TPJ stimulation effect are comparable in the group‐level analysis. Second, the individual‐level analysis reveals that a less right‐lateralized TPJ is associated with a higher level of responsiveness. Participants could be classified into positive responders showing cognitive enhancement and negative responders showing cognitive impairment due to stimulation. The positive responders show weaker connectivity between bilateral TPJ and the medial prefrontal cortex, which mediates the prediction of offline responsiveness by the lateralization and the social‐related trait. These findings call for a better characterization and predictive models for whom tDCS should be used for, and highlight the necessity and feasibility of prestimulation screening.

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“…Before gaming, males demonstrated greater activation of the right striatum, a region implicated in reward processing (Berridge and Kringelbach, 2015 ). Activity in the ventral striatum may influence motivated or goal-directed behaviors (Ikemoto et al , 2015 ; Sayette, 2016 ) and reward processing including in addictions (Balodis and Potenza, 2015 ; Cheng et al , 2016 ; Tobler et al , 2016 ; Yang et al , 2017 ). The striatum may also be activated when individuals are exposed to stimuli related to addictions (Balodis et al , 2012 ; Worhunsky et al , 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Gender-related differences in neural responses to gaming cues before and after gaming: implications for gender-specific vulnerabilities to Internet gaming disorder

Dong

Wang

et al. 2018

Social Cognitive and Affective Neuroscience

104

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BackgroundsMore males than females play video games and develop problems with gaming. However, little is known regarding how males and females who game on the Internet may differ with respect to neural responses to gaming cues.MethodsBehavioral and functional magnetic resonance imaging (fMRI) data were recorded from 40 female and 68 male Internet gamers. This study included three components including participation in a pre-gaming cue-craving task, 30 min of online gaming and a post-gaming cue-elicited-craving task. Group differences were examined at pre-gaming, post-gaming and post- vs pre-gaming times. Correlations between brain responses and behavioral performance were calculated.ResultsGaming-related cues elicited higher cravings in male vs female subjects. Prior to gaming, males demonstrated greater activations in the striatum, orbitofrontal cortex (OFC), inferior frontal cortex and bilateral declive. Following gaming, male subjects demonstrated greater activations in the medial frontal gyrus and bilateral middle temporal gyri. In a post–pre comparison, male subjects demonstrated greater thalamic activation than did female subjects.ConclusionsShort-term gaming elicited in males vs females more craving-related activations to gaming cues. These results suggest neural mechanisms for why males may be more vulnerable than females in developing Internet gaming disorder.

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Electrical stimulation reduces smokers’ craving by modulating the coupling between dorsal lateral prefrontal cortex and parahippocampal gyrus

Cited by 56 publications

References 28 publications

Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues

Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues

Neural and Psychological Predictors of Cognitive Enhancement and Impairment from Neurostimulation

Gender-related differences in neural responses to gaming cues before and after gaming: implications for gender-specific vulnerabilities to Internet gaming disorder

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