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Monodisperse silica‐coated manganese oxide nanoparticles (NPs) with a diameter of ∼35 nm are synthesized and are aminated through silanization. The amine‐functionalized core–shell NPs enable the covalent conjugation of a fluorescent dye, Rhodamine B isothiocyanate (RBITC), and folate (FA) onto their surface. The formed Mn3O4@SiO2(RBITC)–FA core–shell nanocomposites are water‐dispersible, stable, and biocompatible when the Mn concentration is below 50 µg mL−1 as confirmed by a cytotoxicity assay. Relaxivity measurements show that the core–shell NPs have a T1 relaxivity (r1) of 0.50 mM−1 s−1 on the 0.5 T scanner and 0.47 mM−1 s−1 on the 3.0 T scanner, suggesting the possibility of using the particles as a T1 contrast agent. Combined flow cytometry, confocal microscopy, and magnetic resonance imaging studies show that the Mn3O4@SiO2(RBITC)–FA nanocomposites can specifically target cancer cells overexpressing FA receptors (FARs). Findings from this study suggest that the silica‐coated Mn3O4 core–shell NPs could be used as a platform for bimodal imaging (both magnetic resonance and fluorescence) in various biological systems.

‘Internet addiction disorder’ (IAD) is rapidly becoming a prevalent mental health concern in many countries around the world. The neurobiological underpinning of internet addiction should be studied to unravel the potential heterogeneity. The present study examines the neural correlates of response inhibition in males with and without IAD using an event-related functional magnetic resonance imaging (fMRI) Stroop task. The IAD group demonstrated greater ‘Stroop effect’-related activity in the anterior and posterior cingulate cortices (pFDR<0.05) compared to their healthy peers. These results may suggest diminished efficiency of response inhibition processes in the IAD group relative to healthy controls.

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